PMID: 6169822Jun 1, 1981Paper

Enteric transport of chlordecone (Kepone) in the rat

Journal of Pharmacokinetics and Biopharmaceutics
P M BungayH B Matthews

Abstract

Disposition of chlordecone (Kepone) in the rat is quantitated. Particular attention is devoted to the role of the intestinal tract in excretion, as well as absorption, of the parent form of the halogenated pesticide. A detailed physiological pharmacokinetic model for the GI tract is presented in which the organs are segmented into a series of well-mixed compartments representing stomach, small intestine, cecum, and large intestine. The model is applied to the early time behavior of data from the following two types of studies in the rat: (1) the movement of a nonabsorbable tracer along the GI tract, and (2) the enteric transport of parent chlordecone. Model parameter values for the gut wall permeability-area products for parent chlordecone determined for the rat are used to estimate the corresponding values for man based on scale-up considerations. The enhancement of excretion rates through use of orally administered adsorbents is discussed.

References

Feb 2, 1978·The New England Journal of Medicine·W J CohnP S Guzelian
May 1, 1979·Clinical Pharmacology and Therapeutics·J J BoylanP S Guzelian
May 31, 1979·Annals of the New York Academy of Sciences·P M BungayH B Matthews
Feb 1, 1978·Journal of Pharmacokinetics and Biopharmaceutics·D Winne
Mar 1, 1977·Journal of Pharmaceutical Sciences·M E Brady, W L Hayton
Aug 1, 1971·Journal of Pharmaceutical Sciences·K B BischoffJ A Longstreth
Apr 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·D A Clayton, J Vinograd
Aug 1, 1958·The American Journal of Physiology·R C THOMPSON, O L HOLLIS

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Citations

Jan 1, 1993·Life Sciences·F F Farris, R L Dedrick
Aug 1, 1983·Journal of Toxicology and Environmental Health·R E LinderK Powell
Jan 1, 1987·Journal of Toxicology and Environmental Health·P V ShahL L Hall
Jan 1, 1984·Drug Metabolism Reviews·Z H Israili, P G Dayton
Aug 1, 1995·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M F Hughes, L L Hall
May 18, 2005·Journal of Clinical Pharmacy and Therapeutics·M LohitnavyW Srichai
Mar 15, 1983·Toxicology and Applied Pharmacology·F G KingL S Birnbaum
Apr 28, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Lena E FribergMats O Karlsson
Dec 8, 1998·Environmental Research·A C HeatheringtonL L Hall
Jan 1, 1994·Toxicology and Industrial Health·H J Clewell, M E Andersen
Dec 1, 1985·Toxicology and Industrial Health·H J Clewell, M E Andersen
Jan 1, 1984·Critical Reviews in Toxicology·B Clark, D A Smith
Jan 1, 1986·Critical Reviews in Oncology/hematology·R K Jain, L E Gerlowski

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