PMID: 2501612Jun 1, 1989Paper

Enterically transmitted non-A, non-B hepatitis in cynomolgus monkeys: morphology and probable mechanism of hepatocellular necrosis

Liver
S SoeK Mizuno

Abstract

Two cynomolgus monkeys were inoculated with a stool extract originally derived from patients suffering from enterically transmitted non-A, non-B hepatitis. Subsequently, the primates developed self-limiting acute hepatitis and their liver tissues were obtained sequentially by needle biopsy or at sacrifice. Histologically, the liver tissues exhibited necroinflammation which appeared in parallel, both in time and magnitude, with elevation in serum aminotransferases. Necroinflammation was characterized by focal dropout of hepatocytes with accumulation of lymphocytes and macrophages. These lymphocytes were positive for a cytotoxic/suppressor immunophenotype. The hepatocytes surrounding these focal necroses showed depletion of glycogen granules and decrease in glucose-6-phosphatase and succinic dehydrogenase activities. Ultrastructurally, damaged hepatocytes around the focal necroses revealed marked dilatation of both rough and smooth endoplasmic reticula, swelling and disruption of the mitochondria and leakage of nuclear materials into the cytoplasm. Frequently, direct contact between the damaged hepatocytes and lymphocytes was noted. Virus-like particles measuring about 27 nm in diameter were observed singly or in small groups wit...Continue Reading

References

Nov 1, 1985·The American Journal of Tropical Medicine and Hygiene· Hla Myint Khin Maung Tin
Feb 1, 1987·Annals of Internal Medicine·K M De CockA G Redeker
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Citations

Jul 1, 1991·Gastroenterologia Japonica·B N TandonY K Joshi
Jan 1, 1991·Microbiology and Immunology·M IchikawaK Mizuno
May 1, 1990·Journal of Gastroenterology and Hepatology·H GuptaB N Tandon
Mar 17, 2000·Journal of Gastroenterology and Hepatology·R Aggarwal, K Krawczynski
Aug 1, 2002·Current Gastroenterology Reports·Kenneth C Hyams
Nov 23, 2017·Nature Reviews. Gastroenterology & Hepatology·Ila NimgaonkarAlexander Ploss
Jan 1, 1992·Microbiology and Immunology·T UchidaT Rikihisa
Jul 1, 1991·Gastroenterologia Japonica·T UchidaK M Win
Feb 1, 1993·Gastroenterologia Japonica·H GuptaB N Tandon
Jun 13, 1998·Journal of Medical Virology·H van Cuyck-GandréC F Longer
Apr 10, 2003·Journal of Medical Virology·Santosh Man ShresthaHiroaki Okamoto
Oct 31, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jacques BernuauFrançois Durand
Oct 1, 1992·Gastroenterologia Japonica·T Uchida
Jun 15, 2001·ILAR Journal·R H Purcell, S U Emerson

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