Entering the spotlight: hepatitis B surface antigen-specific B cells

The Journal of Clinical Investigation
Christoph Neumann-Haefelin, Robert Thimme

Abstract

Hepatitis B virus-specific (HBV-specific) T cells have been identified as main effector cells in HBV clearance. In contrast, B cells producing neutralizing antibodies against the HBV surface antigen (HBsAg) have been studied in little detail, mainly due to methodical limitations. In this issue of the JCI, two reports use a new technique to specifically detect and characterize HBsAg-specific B cells ex vivo. Indeed, these cells are present, but show phenotypic alterations and impaired function during acute and chronic HBV infection. Thus, HBsAg-specific B cells are a novel attractive target for antiviral strategies toward functional cure of chronic HBV infection.

References

Jun 1, 1993·The Journal of Clinical Investigation·T MaruyamaD R Milich
Apr 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Stefan WielandFrancis V Chisari
Dec 17, 2008·Nature·Vijayakumar VeluRama Rao Amara
Apr 17, 2016·Journal of Hepatology·Antonio Bertoletti, Carlo Ferrari
Jan 5, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Barbara TestoniFabien Zoulim
Jul 25, 2017·Cellular Immunology·Silvia PortugalSusan K Pierce
May 9, 2018·Current Opinion in Virology·Davide CortiDaniel Shouval
Aug 8, 2018·The Journal of Clinical Investigation·Loghman SalimzadehAntonio Bertoletti
Aug 10, 2018·The Journal of Clinical Investigation·Alice R BurtonMala K Maini

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Citations

Sep 25, 2019·Nature Reviews. Gastroenterology & Hepatology·Mala K Maini, Alice R Burton
Aug 13, 2020·International Journal of Molecular Sciences·Janine KemmingChristoph Neumann-Haefelin
Jan 1, 2021·Frontiers in Immunology·Ying Cai, Wenwei Yin
Jun 3, 2021·International Journal of Molecular Sciences·Arshi KhanamShyam Kottilil
Jul 3, 2021·International Journal of Molecular Sciences·Sarah Y NeshatJoshua C Doloff

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