Abstract
Hepatitis B virus-specific (HBV-specific) T cells have been identified as main effector cells in HBV clearance. In contrast, B cells producing neutralizing antibodies against the HBV surface antigen (HBsAg) have been studied in little detail, mainly due to methodical limitations. In this issue of the JCI, two reports use a new technique to specifically detect and characterize HBsAg-specific B cells ex vivo. Indeed, these cells are present, but show phenotypic alterations and impaired function during acute and chronic HBV infection. Thus, HBsAg-specific B cells are a novel attractive target for antiviral strategies toward functional cure of chronic HBV infection.
References
Jun 1, 1993·The Journal of Clinical Investigation·T MaruyamaD R Milich
Dec 2, 1999·Gastroenterology·M K MainiA Bertoletti
Dec 13, 2002·Journal of Virology·Robert ThimmeFrancis V Chisari
Apr 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Stefan WielandFrancis V Chisari
Dec 17, 2008·Nature·Vijayakumar VeluRama Rao Amara
Dec 15, 2010·Journal of Hepatology·Barbara OlivieroMario U Mondelli
Jul 13, 2014·Journal of Hepatology·Bertram BengschRobert Thimme
Apr 8, 2015·Cellular & Molecular Immunology·Xiangsheng XuFu-Sheng Wang
Nov 21, 2015·Gastroenterology·Bijan RaziorrouhTobias Boettler
Apr 17, 2016·Journal of Hepatology·Antonio Bertoletti, Carlo Ferrari
Jul 28, 2016·Cell Reports·Anna SchurichMala K Maini
Jan 5, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Barbara TestoniFabien Zoulim
Feb 7, 2017·Nature Medicine·Paola FisicaroCarlo Ferrari
Feb 22, 2017·Gastroenterology·Rohit Loomba, T Jake Liang
Jul 25, 2017·Cellular Immunology·Silvia PortugalSusan K Pierce
Feb 8, 2018·Gastroenterology·Pascal MutzRalf Bartenschlager
Mar 17, 2018·Gastroenterology·Xiaowen WangLi Tang
May 9, 2018·Current Opinion in Virology·Davide CortiDaniel Shouval
Aug 8, 2018·The Journal of Clinical Investigation·Loghman SalimzadehAntonio Bertoletti
Aug 10, 2018·The Journal of Clinical Investigation·Alice R BurtonMala K Maini
Citations
Sep 25, 2019·Nature Reviews. Gastroenterology & Hepatology·Mala K Maini, Alice R Burton
Oct 15, 2019·Frontiers in Immunology·Zhiyong MaMengji Lu
Aug 13, 2020·International Journal of Molecular Sciences·Janine KemmingChristoph Neumann-Haefelin
Dec 7, 2020·Antiviral Research·Issam ToutTarik Asselah
Jan 1, 2021·Frontiers in Immunology·Ying Cai, Wenwei Yin
Jun 3, 2021·International Journal of Molecular Sciences·Arshi KhanamShyam Kottilil
Jul 3, 2021·International Journal of Molecular Sciences·Sarah Y NeshatJoshua C Doloff