Enteroaggregative Escherichia coli plasmid-encoded toxin

Future Microbiology
Fernando Navarro-Garcia

Abstract

Plasmid-encoded toxin (Pet) is secreted by enteroaggregative Escherichia coli (EAEC), a pathotype of diarrhogenic E. coli. EAEC infection is an important cause of diarrhea in outbreak and nonoutbreak settings in developing and developed countries. EAEC secretes Pet by using the type V secretion system. Mature secreted Pet is a serine protease and its eukaryotic target is the actin-binding protein alpha-fodrin. When Pet cleaves alpha-fodrin in the target cell cytosol, the organization of the actin cytoskeleton is disrupted. The loss of actin filament structure results in cell rounding and detachment from the substratum. This article summarizes the long trip of Pet during its biogenesis, its interaction with epithelial cells, intracellular trafficking and mechanism of action.

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Citations

Jul 17, 2012·Current Gastroenterology Reports·Margarita M P Arenas-HernándezAlfredo G Torres
Jun 21, 2014·BioMed Research International·Rita C RuizRoxane M F Piazza
Sep 6, 2013·Microbiology and Molecular Biology Reviews : MMBR·Vanessa Liévin-Le Moal, Alain L Servin
Apr 27, 2016·Infection and Immunity·Lucia Chavez-DueñasFernando Navarro-Garcia

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Methods Mentioned

BETA
confocal microscopy
light microscopy
protein display

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Actin-binding Proteins

Actin-binding proteins are a component of the actin cytoskeleton that play essential roles in cellular functions such as regulation of actin polymerization, maintenance of cell polarity, gene expression regulation, cell motility and many more functions. Discover the latest research on actin-binding proteins here.