Enterobacter aerogenes OmpX, a cation-selective channel mar- and osmo-regulated

FEBS Letters
Myrielle DupontJ M Pagès

Abstract

The ompX gene of Enterobacter aerogenes was cloned. Its overexpression induced a decrease in the major porin Omp36 production and consequently a beta-lactam resistance was noted. Purified outer membrane protein X (OmpX) was reconstituted into artificial membranes and formed ion channels with a conductance of 20 pS in 1 M NaCl and a cationic selectivity. Both MarA expression and high osmolarity induced a noticeable increase of the OmpX synthesis in the E. aerogenes ATCC 13048 strain. In addition, OmpX synthesis increased under conditions in which the expression of the E. aerogenes major non-specific porins, Omp36 and Omp35, decreased.

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Citations

Jun 7, 2007·European Biophysics Journal : EBJ·Katherine CoxMark S P Sansom
Mar 29, 2005·Antimicrobial Agents and Chemotherapy·Aurélie ThiolasJean-Marie Pagès
Oct 5, 2012·Clinical Microbiology Reviews·Lucía Fernández, Robert E W Hancock
Jun 2, 2011·Canadian Journal of Microbiology·He GaoRuifu Yang
Apr 12, 2007·PloS One·Miguel ViveirosLeonard Amaral
Dec 24, 2013·Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis·Benjamin R CaroneMartin G Marinus
Dec 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·María Antonia Sánchez-Romero, Josep Casadesús
Jul 30, 2009·European Biophysics Journal : EBJ·Laurent J CatoireJean-Luc Popot
Jun 17, 2008·International Journal of Antimicrobial Agents·Ya-Gang ChenLan-Juan Li
Aug 6, 2015·Journal of Medical Microbiology·Elizabeth PinetJean-Marie Pagès
Aug 1, 2015·Omics : a Journal of Integrative Biology·Nilay Budeyri Gokgoz, Berna Sariyar Akbulut
Jan 3, 2013·International Journal of Antimicrobial Agents·Jean-Philippe LavigneAnne Davin-Regli
Oct 22, 2014·PloS One·Annabelle MouammineSophie Gaudriault
Nov 16, 2018·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Patrik Mlynarcik, Milan Kolar
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