Enterobacter aerogenes ZDY01 Attenuates Choline-Induced Trimethylamine N-Oxide Levels by Remodeling Gut Microbiota in Mice

Journal of Microbiology and Biotechnology
Liang QiuHua Wei

Abstract

Trimethylamine N-oxide (TMAO), which is transformed from trimethylamine (TMA) through hepatic flavin-containing monooxygenases, can promote atherosclerosis. TMA is produced from dietary carnitine, phosphatidylcholine, and choline via the gut microbes. Previous works have shown that some small molecules, such as allicin, resveratrol, and 3,3-dimethyl-1-butanol, are used to reduce circulating TMAO levels. However, the use of bacteria as an effective therapy to reduce TMAO levels has not been reported. In the present study, 82 isolates were screened from healthy Chinese fecal samples on a basal salt medium supplemented with TMA as the sole carbon source. The isolates belonged to the family Enterobacteriaceae, particularly to genera Klebsiella, Escherichia, Cronobacter, and Enterobacter. Serum TMAO and cecal TMA levels were significantly decreased in choline-fed mice treated with Enterobacter aerogenes ZDY01 compared with those in choline-fed mice treated with phosphate-buffered saline. The proportions of Bacteroidales family S24-7 were significantly increased, whereas the proportions of Helicobacteraceae and Prevotellaceae were significantly decreased through the administration of E. aerogenes ZDY01. Results indicated that the use...Continue Reading

Citations

Mar 2, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Monia SaviDaniele Del Rio
Jul 28, 2019·Critical Pathways in Cardiology·Vasileios Mantziaris, George Kolios
Feb 29, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Yingqian ZhuHua Jiang
Jul 20, 2020·Heart and Vessels·Tokiko TabataKen-Ichi Hirata
May 13, 2020·Journal of Clinical Medicine·Paula IruzubietaFernando de la Cruz
Jul 4, 2018·Gastroenterology Research and Practice·Jin Bu, Zhaohui Wang
Jan 9, 2019·Hepatology Communications·Suzanne R SharptonSusan V Lynch
Aug 26, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Yixin ZhangJie Du
Dec 8, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Xin ZhaoQilong Wang
Nov 8, 2019·Molecular Nutrition & Food Research·Victoria L O'Morain, Dipak P Ramji
Feb 4, 2021·European Journal of Nutrition·Karen Salve Coutinho-WolinoMilena Barcza Stockler-Pinto
Feb 13, 2021·The Journal of Nutritional Biochemistry·Lisard Iglesias-CarresAndrew P Neilson
Apr 3, 2020·Microorganisms·Hila Korach-RechtmanYechezkel Kashi
Jun 1, 2021·Comprehensive Reviews in Food Science and Food Safety·Alaa El-Din A BekhitDavid L Hopkins
Aug 8, 2021·International Journal of Molecular Sciences·Margaret VourakisGuy Rousseau
Nov 23, 2021·Critical Reviews in Food Science and Nutrition·Yanmin LiFeng Zhang

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