Enterobacteriaceae are essential for the modulation of colitis severity by fungi

Microbiome
Bruno SovranHarry Sokol

Abstract

Host-microbe balance maintains intestinal homeostasis and strongly influences inflammatory conditions such as inflammatory bowel diseases (IBD). Here we focused on bacteria-fungi interactions and their implications on intestinal inflammation, a poorly understood area. Dextran sodium sulfate (DSS)-induced colitis was assessed in mice treated with vancomycin (targeting gram-positive bacteria) or colistin (targeting Enterobacteriaceae) and supplemented with either Saccharomyces boulardii CNCM I-745 or Candida albicans. Inflammation severity as well as bacterial and fungal microbiota compositions was monitored. While S. boulardii improved DSS-induced colitis and C. albicans worsened it in untreated settings, antibiotic treatment strongly modified DSS susceptibility and effects of fungi on colitis. Vancomycin-treated mice were fully protected from colitis, while colistin-treated mice retained colitis phenotype but were not affected anymore by administration of fungi. Antibacterial treatments not only influenced bacterial populations but also had indirect effects on fungal microbiota. Correlations between bacterial and fungal relative abundance were dramatically decreased in colistin-treated mice compared to vancomycin-treated and co...Continue Reading

References

Jan 23, 1999·American Journal of Obstetrics and Gynecology·A SpinilloF Zara
Oct 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Harry SokolPhilippe Langella
Feb 25, 2009·Inflammatory Bowel Diseases·H SokolJ Doré
May 28, 2009·The American Journal of Gastroenterology·Annie Standaert-VitseJean-Frédéric Colombel
Aug 27, 2009·Alimentary Pharmacology & Therapeutics·C Pothoulakis
Feb 13, 2010·Microbiology·Lucy J HolcombeJohn P Morrissey
Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
Aug 17, 2010·Bioinformatics·Robert C Edgar
Feb 1, 2011·Bioinformatics·Robert Schmieder, Robert Edwards
Sep 10, 2011·Bioinformatics·Tanja Magoč, Steven L Salzberg
Sep 28, 2012·Genome Biology·Xochitl C MorganCurtis Huttenhower
Nov 3, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Julie TomasClaire Cherbuy
Oct 12, 2013·Molecular Ecology·Urmas KõljalgKarl-Henrik Larsson
Mar 19, 2014·Cell Host & Microbe·Dirk GeversRamnik J Xavier
Nov 12, 2014·Nature Reviews. Gastroenterology & Hepatology·Pranab K MukherjeeMahmoud A Ghannoum
Dec 30, 2014·Inflammatory Bowel Diseases·Mathias L RichardHarry Sokol
Jun 18, 2015·Inflammatory Bowel Diseases·Christel ChehoudGary D Wu
Jan 18, 2016·The Lancet Infectious Diseases·Marisa HaenniJean-Yves Madec
Feb 5, 2016·Gut·Harry SokolLaurent Beaugerie
Mar 10, 2016·Frontiers in Physiology·Ruan FourieCarolina H Pohl
Sep 20, 2016·Biochemical Pharmacology·Manuel FerrerAndrés Moya
Mar 25, 2017·Scientific Reports·Indu KhatriSrikrishna Subramanian

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Citations

Apr 30, 2019·ESC Heart Failure·Cristiane C K MayerhoferKaspar Broch
May 28, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Martin Kummen, Johannes R Hov
Oct 5, 2019·The Journal of Eukaryotic Microbiology·Katarzyna B Hooks, Maureen A O'Malley
Oct 28, 2019·Alimentary Pharmacology & Therapeutics·Siu LamSiew C Ng
Apr 16, 2020·International Journal of Molecular Sciences·Mario MatijašićDonatella Verbanac
Apr 12, 2020·Journal of Applied Microbiology·Xin MengHao Wu
May 26, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Gaichao HongXiaohua Hou
Feb 28, 2020·Chinese Medical Journal·Peng-Guang Yan, Jing-Nan Li
Jul 2, 2020·Inflammatory Bowel Diseases·Feng ZhuJianfeng Gong
Mar 4, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Paúl A CárdenasManuel E Baldeón
Mar 3, 2019·Nature Reviews. Gastroenterology & Hepatology·Mathias L Richard, Harry Sokol
May 24, 2019·Pathogens·Wibke KrügerMaria Joanna Niemiec
Jan 3, 2020·Mycopathologia·Pei Yee TiewSanjay H Chotirmall
May 21, 2019·Frontiers in Immunology·Klara KostovcikovaMiloslav Kverka
Apr 9, 2020·Frontiers in Immunology·Jarno HonkanenOuti Vaarala
Jul 1, 2020·Advanced Healthcare Materials·Sufeng ZhangGiovanni Traverso
Nov 6, 2020·Journal of Gastroenterology·Lu JiangBernd Schnabl
Dec 6, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Xiali QinHailong Cao
Dec 23, 2020·Microorganisms·Aly KodioStéphane Ranque
Feb 5, 2021·Frontiers in Immunology·Tejpal Gill, James T Rosenbaum
Mar 7, 2021·International Journal of Medical Microbiology : IJMM·J Christian Pérez
Apr 4, 2021·Microorganisms·Valerio BaldelliFederica Del Chierico
Apr 29, 2021·Nature Reviews. Gastroenterology & Hepatology·Camille DanneHarry Sokol
Jun 8, 2021·International Journal of Biological Macromolecules·Xin LiHongliang Zeng
Jul 10, 2021·Gut Microbes·Alessandra FrauChristopher S J Probert
Aug 17, 2021·Scandinavian Journal of Gastroenterology·Sui WangYan-Bo Yu

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Methods Mentioned

BETA
reverse-transcription PCR
ELISA
PCR
GenoScreen

Software Mentioned

GraphPad Prism
PRINSEQ
energy
lite PERL script
QIIME
R
UCLUST
CutAdapt

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