Enterococcal bacteraemia: predictive and prognostic risk factors for ampicillin resistance

Epidemiology and Infection
T MatsumuraS Ichiyama

Abstract

To identify the predictive and prognostic factors associated with ampicillin-resistant enterococcal bacteraemia, we retrospectively reviewed demographic, microbiological and clinical data of patients attending the Kyoto University Hospital, Japan, between 2009 and 2015. Logistic regression and Cox regression analyses were performed to determine the predictive and prognostic factors, respectively. In total, 235 episodes of enterococcal bacteraemia were identified. As ampicillin susceptibility was uniform for Enterococcus faecalis isolates and almost all ampicillin-resistant isolates were E. faecium, bacteraemia due to these species was investigated separately. E. faecalis and E. faecium accounted for 41.7% (98/235) and 48.1% (113/235) of the isolates, respectively and 91.2% of all E. faecium were ampicillin resistant. Nosocomial E. faecium bacteraemia acquisition (odds ratio (OR), 13.6; 95% confidence intervals, 3.16-58.3) was associated with ampicillin-resistant isolates. Bacteraemia from an unknown source (hazard ratio (HR), 2.91; 95% CI 1.36-6.21) and an increased Pitt bacteraemia score (PBS) (HR, 1.36; 95% CI 1.21-1.52) were associated with 30-day mortality in E. faecium infections. Likewise, bacteraemia from an unknown sour...Continue Reading

References

May 1, 1992·Antimicrobial Agents and Chemotherapy·J M BoyceA A Medeiros
Jun 1, 1988·American Journal of Infection Control·J S GarnerJ M Hughes
Feb 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G A NoskinJ R Warren
Jan 9, 1998·Infectious Disease Clinics of North America·D F Sahm, F C Tenover
Apr 26, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D E LowR N Jones
Mar 7, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas P LodiseMichael J Rybak
Dec 4, 2002·The Journal of Antimicrobial Chemotherapy·Jesús FortúnSantiago Moreno
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hilmar WisplinghoffMichael B Edmond
Jul 12, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Carlos A DiazGranadosJohn A Jernigan
Sep 25, 2008·The Journal of Antimicrobial Chemotherapy·Marieke J A de RegtMarc J M Bonten
Nov 17, 2009·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S J McBrideS A Roberts
Aug 17, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D Conde-EstévezH Knobel
Aug 31, 2010·The American Journal of Medicine·Brian C PienMelvin P Weinstein
Nov 28, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M Nagao
May 8, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M PinholtUNKNOWN Danish Collaborative Bacteraemia Network (DACOBAN)
Oct 1, 2013·Expert Review of Cardiovascular Therapy·Anders Dahl, Niels Eske Bruun
May 13, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·E O BillingtonM D Parkins
Nov 9, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Emilio BouzaUNKNOWN Grupo de Apoyo al Manejo de la Endocarditis
May 4, 2015·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Yohei HamadaYosuke Aoki
Jan 29, 2016·International Journal of Clinical Practice·A Pérez-GarcíaJ L Del Pozo
Jun 17, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anders DahlNiels E Bruun
Mar 23, 2017·BMJ Open·Niccolò BuettiUNKNOWN Swiss Centre for Antibiotic Resistance (ANRESIS)
Apr 8, 2017·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Hiroyuki SuzukiNaoto Hosokawa

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
Hiroyuki SuzukiNaoto Hosokawa
The Journal of Infection
N Singh-NazJ M Campos
The Journal of Antimicrobial Chemotherapy
A Simpson, S Barnass
Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases
Hideki AraokaAkiko Yoneyama
© 2022 Meta ULC. All rights reserved