Enterococcus faecalis EF-2001 protects DNBS-induced inflammatory bowel disease in mice model

PloS One
Eun-Ju ChoiEun-Kyung Kim

Abstract

Recent studies have demonstrated the immunomodulatory effects of heat-killed lactic acid bacteria. The aim of this study was to evaluate the protective effect of heat-killed Enterococcus faecalis EF-2001 (EF-2001) on a model of inflammatory bowel disease (IBD). A total of 28 female NC/Nga mice were divided into 4 treatment groups. Controls were fed a normal commercial diet. In the experimental groups, colitis was induced by rectal administration of dinitrobenzene sulfonic acid. Two groups were orally administered 2 and 17 mg/kg EF-2001, respectively. EF-2001 treatment decreased the expression of several cytokines, including cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), interferon (IFN)-γ, interleukin (IL)-1β, and IL-6 in inflamed colon compared to the DNBS alone group. In addition, EF-2001 suppressed DNBS-induced colonic tissue destruction. Therefore, this study strongly suggests that EF-2001 could alleviate the inflammation associated with mouse IBD.

References

Aug 7, 1993·Lancet·N K Boughton-SmithS Moncada
Dec 17, 1994·Lancet·J O LundbergK Alving
Feb 20, 1993·Lancet·S J MiddletonJ O Hunter
Sep 1, 1993·Digestive Diseases and Sciences·S N MurthyD J Sedergran
Aug 1, 1993·The Journal of Applied Bacteriology·M Aguirre, M D Collins
Jan 10, 2001·The Journal of Allergy and Clinical Immunology·M KalliomäkiE Isolauri
Nov 28, 2002·Gastroenterology·Karen Madsen
Oct 13, 2006·Clinical and Experimental Immunology·R ItoO Mazda
May 15, 2007·Lancet·Daniel C Baumgart, William J Sandborn
Feb 19, 2008·Lancet·Marc Gh BesselinkUNKNOWN Dutch Acute Pancreatitis Study Group
Jul 16, 2008·Inflammatory Bowel Diseases·Charles VanderpoolD Brent Polk
Dec 24, 2008·European Journal of Pharmacology·Maria Grazia UrsinoFabrizio De Ponti
Apr 9, 2009·The British Journal of Nutrition·Eduardo J SchiffrinYves Guigoz
Apr 23, 2009·Microbiology·Katie Fisher, Carol Phillips
Feb 16, 2010·Nature Reviews. Immunology·Margarida Saraiva, Anne O'Garra
Mar 3, 2010·Annual Review of Immunology·Arthur KaserRichard S Blumberg
May 12, 2011·Journal of the Science of Food and Agriculture·Chin-Feng LiuTzu-Ming Pan
Jul 26, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Lin-Hua WuHong Yu
Aug 19, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P KochanP B Heczko
Feb 15, 2012·Journal of Visualized Experiments : JoVE·Janice J KimWaliul I Khan
Jun 30, 2012·Korean journal of pediatrics·Nam Yeun Kim, Geun Eog Ji
Oct 9, 2012·Journal of the American Psychoanalytic Association·Diane E Donnelly
Jan 15, 2013·Journal of Ethnopharmacology·Ana Beatriz Albino de AlmeidaCatalina Alarcón de la Lastra
Feb 14, 2013·Genome Announcements·Moritz FritzenwankerEugen Domann
Apr 9, 2013·Bioscience, Biotechnology, and Biochemistry·Ryo InoueKazunari Ushida
Jun 21, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Trishna DebnathBeong Ou Lim
Mar 19, 2014·Journal of Visualized Experiments : JoVE·Vijay MorampudiKevan Jacobson
Aug 31, 2016·Food Science and Biotechnology·Eun-Ju ChoiZee-Yong Park

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Citations

Mar 1, 2020·Applied Microbiology and Biotechnology·Jean Guy LeBlancAlejandra de Moreno de LeBlanc
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hyun-Su Lee, Gil-Saeng Jeong
Jul 7, 2021·Journal of Microbiology and Biotechnology·Young-Jin ChoiEun-Kyung Kim

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