Enteroendocrine K Cells Exert Complementary Effects to Control Bone Quality and Mass in Mice.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Benoît GobronGuillaume Mabilleau

Abstract

The involvement of a gut-bone axis in controlling bone physiology has been long suspected, although the exact mechanisms are unclear. We explored whether glucose-dependent insulinotropic polypeptide (GIP)-producing enteroendocrine K cells were involved in this process. The bone phenotype of transgenic mouse models lacking GIP secretion (GIP-GFP-KI) or enteroendocrine K cells (GIP-DT) was investigated. Mice deficient in GIP secretion exhibited lower bone strength, trabecular bone mass, trabecular number, and cortical thickness, notably due to higher bone resorption. Alterations of microstructure, modifications of bone compositional parameters, represented by lower collagen cross-linking, were also apparent. None of these alterations were observed in GIP-DT mice lacking enteroendocrine K cells, suggesting that another K-cell secretory product acts to counteract GIP action. To assess this, stable analogues of the known K-cell peptide hormones, xenin and GIP, were administered to mature NIH Swiss male mice. Both were capable of modulating bone strength mostly by altering bone microstructure, bone gene expression, and bone compositional parameters. However, the two molecules exhibited opposite actions on bone physiology, with eviden...Continue Reading

References

Apr 1, 1992·European Journal of Clinical Investigation·R EisseleB Göke
Jul 1, 1993·Bone·C H Turner, D B Burr
Dec 1, 1996·Calcified Tissue International·E P PaschalisA L Boskey
Aug 24, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·F Li, R C Mühlbauer
Dec 2, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M AnlaufG E Feurle
Oct 5, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E P PaschalisM Yamauchi
Jan 17, 2002·Bone·N H BjarnasonC Christiansen
Dec 16, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Dennis B HenriksenClaus Christiansen
Aug 10, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A L BoskeyRichard Mendelsohn
Mar 7, 2006·Cell Metabolism·Daniel J Drucker
Dec 30, 2006·Peptides·Helen M Cox
May 15, 2007·Gastroenterology·Laurie L Baggio, Daniel J Drucker
Jun 6, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Patrick AmmannRené Rizzoli
Oct 12, 2007·Physiological Reviews·Jens Juul Holst
Jul 22, 2008·Behavioural Brain Research·Eun Ran KimTooru M Mizuno
Jan 13, 2009·PloS One·Guillaume Mabilleau, Afsie Sabokbar
Oct 21, 2009·The Journal of Pharmacology and Experimental Therapeutics·Jean-Philippe FortinAlan S Kopin
Apr 28, 2010·The Journal of Biological Chemistry·Burton M WiceKenneth S Polonsky
Jun 10, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mary L BouxseinRalph Müller
Jul 6, 2010·Neuroscience Letters·Eun Ran Kim, Tooru M Mizuno
Oct 5, 2010·European Journal of Pharmacology·Pei-Shan LiuTien-Chi Yu
Nov 6, 2010·The Journal of Clinical Endocrinology and Metabolism·Gerard Karsenty, Franck Oury
Dec 4, 2010·The Journal of Biological Chemistry·Guillaume MabilleauAfsie Sabokbar
Dec 1, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·David W DempsterA Michael Parfitt
May 21, 2014·Cell and Tissue Research·Hyun-Jung ChoJohn B Furness
Jul 30, 2014·Bone·Natalie H KellyMarjolein C H van der Meulen
Aug 22, 2014·The Journal of Clinical Endocrinology and Metabolism·Anne NissenBolette Hartmann
Mar 10, 2015·Molecular Endocrinology·Antonella MaffeiPaul E Harris

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Citations

Apr 5, 2020·Nature Reviews. Endocrinology·Claire Greenhill
Apr 7, 2021·British Journal of Pharmacology·Neil TandayNigel Irwin
Jul 26, 2021·Seminars in Cell & Developmental Biology·Morten Steen Hansen, Morten Frost
Aug 24, 2021·Frontiers in Endocrinology·Aleksandra MieczkowskaGuillaume Mabilleau

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