Enterogastric brake in rats with segmental bowel resection: role of capsaicin-sensitive nerves

Clinical and Experimental Pharmacology & Physiology
Tuğba TopçuCumhur Yeğen

Abstract

1. Unabsorbed nutrients in the distal gut inhibit upper gastrointestinal motility. 2. The aim of the present study was to investigate changes in gastric motility following segmental resections and to evaluate the role of capsaicin-sensitive afferent neurons that may be responsible for these changes. 3. Wistar albino rats of both sexes (200-250 g) were used. Under aseptic conditions and anaesthesia (100 mg/kg ketamine), a baby-feeding tube was placed distal to the resection in either the ileum or caecum for intraluminal perfusion of saline or 20 lipid. In one group of rats, capsaicin was perfused (0.6) for afferent denervation. One group of rats underwent jejunal and ileal resections with end-to-end anastomosis of the remaining segments and were cannulated distal to these anastomosis. Ten days after the surgery, the percentage gastric emptying of a solid meal was calculated. 4. Intra-ileal (18) and intracaecal (34) lipid perfusions delayed gastric emptying compared with groups perfused with saline (54 and 74, respectively; P< 0.001 and P< 0.01). The delay in gastric emptying by ileal perfusion was significantly greater than that following caecal perfusion (P< 0.05). With both resections, gastric emptying was delayed compared wit...Continue Reading

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Citations

Dec 21, 2016·Digestive Diseases and Sciences·Savio G Barreto, John A Windsor
Oct 10, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David W NelsonDenise M Ney
Mar 26, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Anders Lehmann, Pamela J Hornby

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