PMID: 1195117Nov 1, 1975Paper

Enterohepatic circulation of tetracycline in rats

Journal of Pharmaceutical Sciences
J Adir

Abstract

The absorption of tetracycline hydrochloride excreted in the bile of rats was evaluated using the insitu intestinal preparation. For comparative purposes, the absorption of the drug from an aqueous solution having the same pH as that of the bile was also determined. After 4 hr, the amounts of tetracycline absorbed from the bile and aqueous solutions were 72.92 and 77.34%, respectively. There was no significant difference in the amount of drug accumulated in the gut tissue. The disappearance of the drug from the intestinal lumen was biexponential, and the kinetic parameters appeared to be similar. It was concluded that tetracycline excreted in the bile is readily absorbed from the rat intestine. Accordingly, biliary excretion does not seem to account for a significant elimination of this antibiotic from the body.

References

Jan 1, 1971·Chemotherapy·M Schach von Wittenau, T M Twomey
Jan 1, 1972·Chemotherapy·M Schach VON WITTENAUA C Swindell

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Citations

Mar 1, 1977·Journal of Toxicology and Environmental Health·H E Gallo-Torres
Nov 9, 2011·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·F YangZ L Zeng
May 21, 2010·Clinical Pharmacokinetics·Neal M DaviesJaime A Yáñez
May 1, 1983·Journal of Pharmaceutical Sciences·D M Cocchetto, T D Bjornsson
Sep 1, 1979·Journal of Pharmaceutical Sciences·L Olanoff, J M Anderson
Jul 1, 1977·Journal of Pharmaceutical Sciences·J Adir, W H Barr
Dec 1, 1980·Journal of Pharmacokinetics and Biopharmaceutics·L S Olanoff, J M Anderson
Nov 7, 2018·The Journal of Pharmacology and Experimental Therapeutics·Jacopo LucchettiMarco Gobbi
Mar 25, 2017·Archives of Toxicology·C BehrB van Ravenzwaay

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