PMID: 3766051Sep 1, 1986Paper

Enterohepatic recirculation of oestriol: inhibition by activated charcoal

Acta Endocrinologica
G Heimer, D Englund

Abstract

We have earlier reported on a prolonged effect of orally administered oestriol caused by its enterohepatic recycling after reabsorption from the intestine. The aim of the present study was to test if oral administration of activated charcoal could inhibit the enterohepatic recirculation of orally given oestriol. Plasma concentrations of unconjugated oestriol were measured using a specific radioimmunoassay (RIA). Twelve mg oestriol administered orally to postmenopausal women resulted in elevated plasma oestriol levels for more than 24 h. Plasma oestriol fluctuations in relation to meals were seen. When activated charcoal was given 3 h after oestriol administration, the plasma oestriol concentration declined without further fluctuations and returned to the pretreatment value within 6 h. Our data indicate that oestriol given orally undergoes enterohepatic recirculation after reabsorption from the intestine since administration of charcoal, which binds steroids, resulted in a rapidly declining oestriol level. It is concluded that the prolonged oestriol elevation, which is normally seen, is caused by enterohepatic recycling.

Citations

Jun 13, 2003·Research in Veterinary Science·M HoeijmakersL Horspool
Dec 25, 2012·Journal of Translational Medicine·Roberto FloresJames J Goedert
Oct 6, 1998·Journal of Pharmaceutical Sciences·T M MorganB C Finnin
Jan 1, 1988·Medical Toxicology and Adverse Drug Experience·P J Neuvonen, K T Olkkola
Aug 23, 2005·Climacteric : the Journal of the International Menopause Society·H Kuhl
Aug 7, 2002·Clinical Pharmacokinetics·Michael S RobertsMichael Weiss
Mar 19, 2016·Drug Metabolism Reviews·Mohd Yaseen MalikJawahar Lal
Sep 29, 1998·The Journal of Pharmacy and Pharmacology·T B Vree, C J Timmer
Jan 5, 2001·Human Reproduction·K ElomaaP Lähteenmäki
Aug 24, 2021·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Lotte C G HoegbergSophie Gosselin

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