Enteromorpha prolifera Extract Improves Memory in Scopolamine-Treated Mice via Downregulating Amyloid-β Expression and Upregulating BDNF/TrkB Pathway

Antioxidants
Seung Yeon BaekMee Ree Kim

Abstract

Enteromorpha prolifera, a green alga, has long been used in food diets as well as traditional remedies in East Asia. Our preliminary study demonstrated that an ethyl acetate extract of Enteromorpha prolifera (EAEP) exhibited the strongest antioxidant activity compared to ethanol or water extracts. Nonetheless, there has been no report on the effect of EAEP on memory impairment due to oxidative damage. This study investigated whether EAEP could attenuate memory deficits in an oxidative stress-induced mouse model. EAEP was orally administered (50 or 100 mg/kg body weight (b.w.)) to mice and then scopolamine was administered. The oral administration of EAEP at 100 mg/kg b.w. significantly restored memory impairments induced by scopolamine, as evaluated by the Morris water maze test, and the passive avoidance test. Further, EAEP upregulated the protein expression of BDNF, p-CREB, p-TrkB, and p-Akt. Moreover, EAEP downregulated the expression of amyloid-β, tau, and APP. The regulation of cholinergic marker enzyme activities and the protection of neuronal cells from oxidative stress-induced cell death in the brain of mice via the downregulation of amyloid-β and the upregulation of the BDNF/TrkB pathway by EAEP suggest its potential a...Continue Reading

References

Mar 1, 1986·Behavioral and Neural Biology·J F Flood, A Cherkin
May 1, 1984·Journal of Neuroscience Methods·R Morris
Mar 26, 1998·Experimental Neurology·D L MarcusM L Freedman
Sep 25, 1998·Neurology·A F Jorm, D Jolley
Feb 19, 2000·The American Journal of Clinical Nutrition·Y Christen
Apr 30, 2003·Journal of Pharmacological Sciences·Kiyofumi Yamada, Toshitaka Nabeshima
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Aug 11, 2004·Behavioural Brain Research·Arjan BloklandMarin Been
Apr 13, 2005·Trends in Molecular Medicine·Frank M LaFerla, Salvatore Oddo
Jun 23, 2005·International Archives of Allergy and Immunology·Hiroko MaruyamaTakahisa Nakano
Jul 11, 2006·Journal of Neuropathology and Experimental Neurology·Akihiko NunomuraMark A Smith
Jun 7, 2007·Nature Reviews. Neuroscience·Frank M LaFerlaSalvatore Oddo
Jul 3, 2007·Cellular and Molecular Life Sciences : CMLS·X ZhuG Perry
Oct 4, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Pedro BekinschteinJorge H Medina
Oct 12, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marina YamadaMasaaki Matsuoka
Jan 1, 2008·Annals of Indian Academy of Neurology·Shrikant Mishra, Kalpana Palanivelu
May 12, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Soo-Jin HeoYou-Jin Jeon
Jun 16, 2011·Marine Drugs·Ratih Pangestuti, Se-Kwon Kim
Sep 13, 2011·International Journal of Biological Macromolecules·Jin-Kyung KimSang Guan You
Apr 2, 2013·International Journal of Biological Macromolecules·Zhihong TangSong Qin
Jun 26, 2013·Food Chemistry·Kannan R R RengasamyJohannes Van Staden
Jul 10, 2013·Current Medicinal Chemistry·C GrossoP B Andrade
Dec 4, 2013·International Journal of Biological Macromolecules·Jianteng WeiDuolong Di
Dec 30, 2014·Journal of Medicinal Food·Chun Nan DuMee Ree Kim
Jul 21, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·N BoublayP Krolak-Salmon
Nov 24, 2017·Frontiers in Immunology·Sara V Maurer, Christina L Williams
Nov 5, 2019·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Ju GaoXinglong Wang
Dec 4, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kannan Rr RengasamyDoo Hwan Kim

❮ Previous
Next ❯

Methods Mentioned

BETA
protein assay
MDA
X-ray

Software Mentioned

Image J
GraphPad Prism
SPSS

Related Concepts

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.