PMID: 2496216Apr 1, 1989Paper

Enteropathy and renal involvement in an infant with evidence of widespread autoimmune disturbance

Journal of Pediatric Gastroenterology and Nutrition
S G MittonJ A Walker-Smith

Abstract

An 8-month-old infant presented with a 1 month history of protracted diarrhea, vomiting, and weight loss. Small intestinal biopsy showed a flat mucosa and there was no clinical improvement with gluten, cow's milk protein, and disaccharidase-free diet. Serial testing for autoantibodies revealed persistent autoantibodies to gut epithelial cells and to renal brush borders; on two occasions, atypical liver-kidney microsomal antibodies were detected. Treatment with steroids produced clinical improvement but the patient finally succumbed with a combination of gut and renal dysfunction. The widespread nature of the antibodies, with clinical involvement of gut, liver, and kidney, suggest an underlying autoimmune mechanism for the pathogenesis of the condition. Serial autoantibody measurements may provide a means to monitor the disease progress and may be a guide to treatment.

Citations

Sep 4, 2003·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·E Bernardos, J A Solís-Herruzo
Feb 11, 2005·Current Opinion in Gastroenterology·Frank M RuemmeleOlivier Goulet
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Sep 21, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Aatur D SinghiSarangarajan Ranganathan
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