PMID: 9649024Jul 2, 1998Paper

Enteropathy-associated T cell lymphoma with brain involvement

Journal of Clinical Gastroenterology
E L BermanP G Isaacson

Abstract

In a patient with enteropathy-associated T cell lymphoma. there was dissemination to the brain manifesting as an inflammatory lesion. the intestinal and brain lesions were studied using routine histology, immunohistochemistry, and polymerase chain reaction. The jejunum was involved by a multifocal large cell lymphoma associated with multiple inflammatory ulcers and villous atrophy with crypt hyperplasia of the intervening mucosa. The lesion in the brain consisted of necrotic tissue associated with an infiltrate of histiocytes and a relatively scant infiltrate of primarily small lymphocytes. The appearance was that of an inflammatory rather than a neoplastic process. The intestinal lymphoma cells were positive for T cell markers and contained cytotoxic granules detected with the TIA-1 monoclonal antibody. The small lymphocytes and occasional large cells in the cerebral lesion showed the same immunophenotype. DNA extracted from the intestinal lymphoma and the cerebral lesion showed identical monoclonal rearrangement of the TCR-gamma gene. Dissemination from enteropathy-associated T cell lymphoma may masquerade as an inflammatory lesion. Molecular analysis is useful in confirming the diagnosis.

Citations

Sep 14, 2011·Current Hematologic Malignancy Reports·Michal K Sieniawski, Anne L Lennard
Dec 12, 2012·Surgical Neurology International·Archie DefilloEric S Nussbaum
Oct 6, 2005·Clinical Neurology and Neurosurgery·M DoranA J Larner
Feb 15, 2018·Current Hematologic Malignancy Reports·Parwiz J Siaghani, Joo Y Song
Jan 2, 2021·World Journal of Gastroenterology : WJG·Lena HorvathSarah Iglseder

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