Enterotoxaemia in goats

Veterinary Research Communications
F Uzal, W R Kelly

Abstract

Enterotoxaemia of sheep and goats occurs worldwide, but the condition in goats is poorly understood. The disease in goats is mostly caused by Clostridium perfringens type D, although the role of the toxins of this microorganism in the pathogenesis of the disease is not fully understood. The disease occurs in three forms, peracute, acute and chronic, the cardinal clinical sign of the acute and chronic forms being diarrhoea. The main biochemical alterations are hyperglycaemia and glycosuria, while at necropsy the disease is often characterized by haemorrhagic colitis. The typical histological changes observed in the brain of sheep with enterotoxaemia are not considered to be a common feature of enterotoxaemia in goats. Although the pathogenesis of caprine enterotoxaemia has not yet been properly defined, it is usually accepted that the presence of C. perfringens type D in the small bowel, together with a sudden change to a diet rich in carbohydrates, is the main predisposing factor for the disease. Vaccination seems to be poorly effective in preventing caprine enterotoxaemia, which might be due to the fact that the enteric form of the disease is partially independent of circulating C. perfringens toxin. More studies are needed on...Continue Reading

References

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Citations

Jun 15, 2007·Infection and Immunity·Mariano E Fernandez-MiyakawaFrancisco A Uzal
Oct 15, 2009·Future Microbiology·Michel R Popoff, Philippe Bouvet
Jul 15, 2009·Acta Tropica·M Tariq JavedRiaz Hussain
May 4, 2011·The FEBS Journal·Michel R Popoff
May 2, 2013·Toxicon : Official Journal of the International Society on Toxinology·Laetitia WiolandBernard Poulain
Sep 9, 2008·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Francisco A UzalSharon Gard
Mar 29, 2003·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·F A UzalF Galea
Apr 16, 1998·Veterinary Pathology·F A Uzal, W R Kelly
May 8, 2008·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Francisco A Uzal, J Glenn Songer
Jan 22, 2019·Veterinary Pathology·Joaquín OrtegaFrancisco A Uzal
Aug 30, 1997·The Veterinary Record·F A UzalR Thomas

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