Enterotoxigenic Escherichia coli targeting intestinal epithelial tight junctions: An effective way to alter the barrier integrity

Microbial Pathogenesis
J Daniel Dubreuil

Abstract

Enterotoxigenic Escherichia coli are responsible for causing secretory diarrhea in animal(s), including human(s). This group of microorganisms is classified on the basis of production of toxins acting on the intestinal epithelium of the small intestine. Various enterotoxins, heat-labile and heat-resistant, are produced by distinct strains of ETEC. Although the mechanisms of action of ETEC enterotoxins were shown to involve diverse ion channels recent data suggest that these molecules could also be involved in disruption of the permeability barrier of the intestinal epithelium. More precisely, the tight junctions directly responsible for the selective permeability of the intestinal tissue could be affected. Studies indicating a change in TJ following exposure of cell monolayers or animal models either to pure enterotoxins or to ETEC strains producing one or more of these toxic molecules will be discussed.

Citations

Oct 16, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xinpeng JiangDi Liu
Sep 1, 2019·Digestive Diseases and Sciences·Daniel Hollander, Jonathan D Kaunitz
Oct 9, 2018·Frontiers in Microbiology·Diliana Pérez-ReytorKatherine García
Nov 25, 2020·Microbial Pathogenesis·Tianfeng MaYongxiang Tian
Mar 7, 2021·Animals : an Open Access Journal From MDPI·Andrea BonettiEster Grilli
Apr 4, 2021·Microorganisms·Daniel SánchezHelena Tlaskalová-Hogenová
Aug 20, 2021·Advanced Drug Delivery Reviews·Yuandong ZhangXun Sun

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