PMID: 9175007Apr 1, 1997Paper

Enterotropic mouse hepatitis virus

Laboratory Animals
F R Homberger

Abstract

Mouse hepatitis virus [MHV], the coronavirus of the mouse, is the most common viral pathogen in contemporary laboratory mouse colonies throughout the world. It is highly contagious with variable clinical manifestations. The majority of infections are subclinical, but can still significantly influence biological responses, thus interfering with research, mainly in the field of immunology. MHV has been intensively studied from a number of research perspectives and has become the prototype for studying the molecular biology of coronaviruses. MHV contains a single-stranded, positive-sense RNA genome ranging from 27 to 31 kb, which is divided into seven genes. Virions consist of four to five structural proteins. There are many MHV strains that vary in virulence, organotropism and cell tropism, and are constantly evolving by naturally occurring mutation and recombination. Based on pathogenesis studies MHV strains are usually grouped according to their primary tissue tropism into two biotypes: polytropic and enterotropic. Enterotropic strains of MHV replicate in the intestinal mucosa and only rarely spread to other tissues. No morphological structure of the virion has as yet been identified that is responsible for enterotropism. The c...Continue Reading

Citations

Oct 30, 2012·Ontogenez·I N RozhkovaS Ia Amstislavskiĭ
Dec 31, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Wei YangZhihai Qin
Jan 13, 2015·Current Biology : CB·Madlaina BoillatIvan Rodriguez
Jul 6, 2011·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Christian LawrenceGeorge E Sanders
Mar 7, 2008·Cytokine & Growth Factor Reviews·Volker Thiel, Friedemann Weber
Jul 18, 2009·Current Opinion in Microbiology·Luis P Villarreal
May 20, 2014·The Veterinary Journal·Niels C Pedersen
Nov 6, 2012·Journal of Virological Methods·Ken-Ichi HanakiNorio Hirano
Dec 9, 2004·The Veterinary Clinics of North America. Exotic Animal Practice·Corinna KashubaCraig Franklin
Jan 4, 2003·Nature Reviews. Immunology·Ian Nicholas Crispe
Dec 12, 2018·Immunology and Cell Biology·Katharine J GoodallDaniel M Andrews
Feb 14, 2006·Clinical & Experimental Metastasis·Juan Rodríguez-CuestaGuillermo Martínez de Tejada
Jul 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lara MyersKim J Hasenkrug
Dec 31, 2016·The Journal of Biological Chemistry·Guiqing PengFang Li
Apr 19, 2018·MBio·Simon H WilliamsW Ian Lipkin
Dec 17, 2020·Animals : an Open Access Journal From MDPI·Valentina ZappulliMassimo Castagnaro
Mar 12, 2021·Virus Research·Santiago Emanuel ColinaGermán Ernesto Metz
Apr 1, 2021·Open Biology·Monikaben PadariyaAlicja Sznarkowska

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