Enteroviral meningitis: natural history and outcome of pleconaril therapy

Antimicrobial Agents and Chemotherapy
R A DesmondR J Whitley

Abstract

Enteroviral meningitis causes appreciable morbidity in adults, including hospitalization, decreased activity, and headache. Limited data define the natural history of disease. No antiviral therapeutic agent has demonstrated improved outcome in controlled clinical trials. Pleconaril, an inhibitor of enterovirus replication, was tested in two placebo-controlled clinical trials. Of 607 randomized patients in a multicenter, double-blind placebo-controlled study of pleconaril (200 mg three times daily versus an identical-appearing placebo), 240 patients were confirmed to have enterovirus infection. The time to headache resolution was evaluated by using Kaplan-Meier survival methodology. A Cox regression model evaluated multivariate factors associated with disease resolution. Resolution of headache in patients with concomitant moderate to severe nausea at baseline occurred at a median of 9.5 days in the absence of therapy and was reduced to 7.0 days for pleconaril recipients (P = 0.009). For a headache score of > 5 alone, treated patients resolved headache significantly more rapidly (P = 0.005). Males resolved headache 50% faster than females. Regardless of randomization group, patients with a baseline headache score of 5 or greater ...Continue Reading

References

Jan 1, 1990·Social Science & Medicine·D D CelentanoW F Stewart
Oct 1, 1995·Annals of Emergency Medicine·K A RafteryA H Chen
Apr 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H A Rotbart
Nov 3, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H A RotbartF G Hayden
Sep 3, 1999·Antimicrobial Agents and Chemotherapy·D C PevearJ M Groarke
Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H A RotbartUNKNOWN Pleconaril Treatment Registry Group
Feb 15, 2001·Expert Opinion on Investigational Drugs·J R Romero
Sep 6, 2001·Journal of Medical Virology·M ChambonH Peigue-Lafeuille
Jul 18, 2002·Dermatologic Clinics·Jennifer R Stalkup, Suneel Chilukuri
Apr 12, 2003·The Pediatric Infectious Disease Journal·Mark J AbzugUNKNOWN National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group

❮ Previous
Next ❯

Citations

Jan 14, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Erin S HaleyDarren R Shafren
Jun 27, 2008·Current Treatment Options in Neurology·Larry E Davis
Dec 29, 2007·The Pediatric Infectious Disease Journal·Rosa Maria Pino-RamírezCarmen Muñoz-Almagro
Jan 28, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Hagai LevineMichael Huerta-Hartal
Dec 1, 2007·Expert Opinion on Medical Diagnostics·Yi-Wei Tang
Aug 13, 2015·Viruses·Lonneke van der LindenFrank J M van Kuppeveld
Jul 9, 2013·Critical Care Clinics·Andreas H Kramer
Jan 17, 2012·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·H SantosF Santos
Jul 29, 2008·Neurologic Clinics·David N Irani
Nov 29, 2011·The Journal of Infection·R KneenUNKNOWN National Encephalitis Guidelines Development and Stakeholder Groups
Nov 29, 2011·The Journal of Infection·T SolomonUNKNOWN National Encephalitis Guidelines Development and Stakeholder Groups
Jan 31, 2012·Neurologic Clinics·Amy A Pruitt
Nov 9, 2010·Advances in Pediatrics·E Richard StiehmHeather Lehman
Mar 24, 2009·Seminars in Fetal & Neonatal Medicine·Marc Tebruegge, Nigel Curtis
Jun 3, 2008·Neurologic Clinics·Wendy C Ziai, John J Lewin
Dec 25, 2010·Journal of Medical Virology·Christina B PlanitzerThomas R Kreil
May 4, 2012·Medicinal Research Reviews·Erik De Clercq
Jan 22, 2011·Virology·Ross E RhoadesRalph Feuer
Jun 30, 2014·Bioorganic & Medicinal Chemistry·Angela M BernardRaffaello Pompei
Sep 26, 2015·Journal of the Pediatric Infectious Diseases Society·John F Modlin
Sep 26, 2015·Journal of the Pediatric Infectious Diseases Society·Mark J AbzugUNKNOWN National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group
May 9, 2016·European Journal of Pediatrics·S C M de CromC C Obihara
Jan 25, 2017·Current Opinion in Infectious Diseases·Fiona McGillTom Solomon
Apr 28, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Samuela LaconiRaffaello Pompei
May 2, 2007·Current Opinion in Infectious Diseases·Bonita E Lee, H Dele Davies
Apr 24, 2010·Current Opinion in Infectious Diseases·Heli HarvalaPeter Simmonds
Sep 2, 2014·Pathogens and Global Health·Shikha JainGirish Chandra Bhatt
Dec 1, 2019·BMC Infectious Diseases·Jonas GrafPhilipp Albrecht
Jan 5, 2021·Archives of Virology·Amira KohilHadi M Yassine
Oct 13, 2018·The Medical Journal of Australia·Miles H Beaman
Jul 6, 2021·Frontiers in Medicine·Shilu MathewHadi M Yassine

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

The Pediatric Infectious Disease Journal
Mark J AbzugNational Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
M J AbzugH A Rotbart
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Katja C WolthersDasja Pajkrt
Current Opinion in Infectious Diseases
Heli HarvalaPeter Simmonds
The Pediatric Infectious Disease Journal
Malgorzata A Verboon-MaciolekAnton M van Loon
© 2021 Meta ULC. All rights reserved