Enterovirus 71 infection causes severe pulmonary lesions in gerbils, meriones unguiculatus, which can be prevented by passive immunization with specific antisera

PloS One
Fang XuHan-Ping Zhu

Abstract

Neurogenic pulmonary edema caused by severe brainstem encephalitis is the leading cause of death in young children infected by Enterovirus 71 (EV71). However, no pulmonary lesions have been found in EV71-infected transgenic or non-transgenic mouse models. Development of a suitable animal model is important for studying EV71 pathogenesis and assessing effect of therapeutic approaches. We had found neurological disorders in EV71-induced young gerbils previously. Here, we report severe pulmonary lesions characterized with pulmonary congestion and hemorrhage in a gerbil model for EV71 infection. In the EV71-infected gerbils, six 21-day-old or younger gerbils presented with a sudden onset of symptoms and rapid illness progression after inoculation with 1×105.5 TCID50 of EV71 via intraperitoneal (IP) or intramuscular (IM) route. Respiratory symptoms were observed along with interstitial pneumonia, pulmonary congestion and extensive lung hemorrhage could be detected in the lung tissues by histopathological examination. EV71 viral titer was found to be peak at late stages of infection. EV71-induced pulmonary lesions, together with severe neurological disorders were also observed in gerbils, accurately mimicking the disease process in E...Continue Reading

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Citations

Dec 24, 2015·Viruses·Prabuddha S PathinayakePeter A B Wark
Oct 23, 2010·Lancet Neurology·Mong How OoiTom Solomon
May 17, 2018·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yuefei JinGuangcai Duan
Jul 1, 2016·Scientific Reports·Carla Bianca Luena VictorioKaw Bing Chua

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Methods Mentioned

BETA
transgenic

Software Mentioned

GraphPad
GraphPad Prism
SPSS

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