Enterovirus infection during pregnancy is inversely associated with atopic disease in the offspring

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
Laura KorhonenHeikki Hyöty

Abstract

Prenatal environment has been shown to influence child's risk of atopic diseases. Laboratory-confirmed data about the role of maternal infections during pregnancy is scarce. The aim of this study was to determine the associations between serologically confirmed maternal infections during pregnancy and atopic disease in the offspring. This was a nested case-control study within a prospective birth cohort study. Altogether 202 atopic case children and 333 matched non-atopic control children were included. Atopic outcome was defined as having an atopic disease and IgE sensitization by the age of 5 years. We analysed serologically acute enterovirus (EV), influenza virus A (IAV) and Mycoplasma pneumoniae (M. pneumoniae) infections during pregnancy, and mother's seropositivity against human cytomegalovirus (CMV) and Helicobacter pylori. Maternal EV infection during pregnancy was inversely associated with atopic outcome in the offspring (odds ratio 0.43; 95% confidence interval: 0.23-0.80, P = 0.008). Acute IAV or M. pneumoniae infections or seropositivity against CMV or Helicobacter pylori were not associated with the atopic outcome. Our results suggest that maternal EV infections during pregnancy are inversely associated with atopic...Continue Reading

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Citations

Dec 14, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Graham RobertsJ A Woodfolk
Jul 6, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Tiina PalmuHeikki Hyöty

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