Enterovirus markers and serum CXCL10 in children with type 1 diabetes

Journal of Medical Virology
Anna-Karin BergGun Frisk

Abstract

Most patients with type 1 diabetes are considered to have a T-cell mediated autoimmune disease. The chemokine CXCL10 promotes the migration of activated T-cells. Virus infections might contribute to the pathogenesis of type 1 diabetes and enterovirus protein and/or genome have been detected in beta-cells from a majority of tested newly diagnosed children with type 1 diabetes. The chemokine CXCL10 is induced in human islet cells by enterovirus infections in vivo and in vitro, but is not expressed in islets from normal organ donors. Since CXCL10 is a chemokine known to be induced by virus infections and/or cellular damage, our aim was to study if levels of CXCL10 are elevated in serum from children with type 1 diabetes and whether it correlates to the presence of enterovirus markers. CXCL10, neutralizing antibody titer rises against certain enterovirus, and antibodies against GAD65 were measured in serum, and enterovirus PCR was performed on whole blood from 83 type 1 diabetes patients at onset, 48 siblings and 69 controls. CXCL10 was also measured in serum from 46 patients with proven enterovirus infection and in serum from 46 patients with other proven virus infections. The CXCL10 serum levels were not elevated in children at o...Continue Reading

References

May 24, 1979·The New England Journal of Medicine·J W YoonA L Notkins
Jan 1, 1997·Annual Review of Immunology·M BaggioliniB Moser
Jul 3, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·C NairnG B Clements
Jun 3, 2000·Annual Review of Immunology·D Rossi, A Zlotnik
Oct 26, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G R VreugdenhilJ M Galama
Apr 6, 2001·Diabetes Care·A ShimadaS Narumi
Jan 1, 2004·The Journal of Clinical Investigation·Urs ChristenMatthias G von Herrath
Mar 20, 2004·Clinical and Experimental Immunology·S HoppuUNKNOWN Childhood Diabetes in Finland Study Group
Dec 2, 2004·Journal of Autoimmunity·Sanna HoppuUNKNOWN Childhood Diabetes in Finland Study Group
May 20, 2005·Journal of Medical Virology·Eduardo Cabrera-RodeOscar Díaz-Horta
May 25, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Maria HinderssonFrisk Gun
Aug 12, 2005·World Journal of Gastroenterology : WJG·Dong LiGuo-Liang Liu
Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Antje RhodeUrs Christen
May 24, 2006·Clinical and Experimental Dermatology·J WenzelT Tüting
Dec 3, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·A AntonelliE Ferrannini

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Citations

Feb 18, 2014·Cytokine & Growth Factor Reviews·Alessandro AntonelliPoupak Fallahi
Jun 7, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susan J BurkeJ Jason Collier

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