Abstract
Enterovirus meningitis is well documented in children. However, there is a paucity of reports in adults, despite the availability of genome detection (RT-PCR) in cerebrospinal fluid (CSF), which provides a rapid and reliable diagnosis. The clinical course and management of 30 cases of entero-virus proven meningitis prospectively diagnosed between August 1999 and November 2000 in immunocompetent adults were analysed, and laboratory and clinical strategies evaluated. Patient age ranged between 17 and 43 (median 29). The analysis of clinical, biological, and epidemiological data showed the difficulty of recognising enterovirus meningitis in adults. Characteristic symptoms were either inconstant (the association of fever/headache/stiff neck) or misleading (the presence of vesicular lesions). CSF data showed moderate pleocytosis but a predominance of lymphocytes in only 12/27 (44%) patients. An epidemiological background was present in 10/30 (33%) patients, but 10/30 (33%) patients were admitted during cold months. Consequently, although the detection of enterovirus genome in CSF was positive in all cases, the results were communicated within a median of 6 days [2-9] after admission, mainly because the aetiology was not considered e...Continue Reading
References
Nov 17, 1989·JAMA : the Journal of the American Medical Association·A SpanosD T Durack
May 1, 1987·Acta Neurologica Scandinavica·E KinnunenM L Kantanen
May 1, 1995·Journal of Virological Methods·I CasasG M Cleator
Dec 1, 1994·Journal of Virological Methods·A SakrauskiH W Doerr
Apr 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S K RiceS M Opal
May 1, 1994·The Journal of Infectious Diseases·R F HelfandL J Anderson
Nov 1, 1995·The Journal of Infection·I MoriY Kimura
Nov 3, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H A RotbartF G Hayden
Sep 7, 1999·Public Health Reports·J C Mohle-BoetaniS L Solomon
Oct 30, 1999·European Journal of Epidemiology·U C ViethL R Petersen
May 3, 2000·Clinical Pediatrics·V M SpicherC A Siegrist
May 20, 2000·JAMA : the Journal of the American Medical Association·C RamersM H Sawyer
Aug 2, 2000·Archives of Pediatrics & Adolescent Medicine·L E Nigrovic, V W Chiang
Mar 20, 2001·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·C HenquellH Peigue-Lafeuille
Sep 6, 2001·Journal of Medical Virology·M ChambonH Peigue-Lafeuille
Citations
Oct 12, 2002·Journal of Medical Virology·Jean-Luc BaillyHélène Peigue-Lafeuille
Jan 23, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pierre QuartierMarc Tardieu
Apr 13, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Laura KupilaPirkko Kotilainen
Jul 3, 2004·Medicine·Emmanuelle BernitRémi N Charrel
Jul 22, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F FrantzidouA Papa
Oct 9, 2003·Journal of Clinical Microbiology·Christine ArchimbaudHélène Peigue-Lafeuille
Sep 15, 2004·Journal of Clinical Microbiology·William S MulfordGregory A Storch
Jul 23, 2013·PloS One·Christine ArchimbaudHélène Peigue-Lafeuille
Apr 15, 2005·Emerging Infectious Diseases·Yan Na ZhaoDavid S Perlin
Mar 22, 2014·The Journal of Infectious Diseases·Romain VolleChristine Archimbaud
Nov 6, 2012·Neuroimaging Clinics of North America·James Riddell, Emily K Shuman
Jun 20, 2012·The Journal of Emergency Medicine·Michael M Mohseni, James A Wilde
Nov 26, 2008·Journal of Medical Virology·C ArchimbaudH Peigue-Lafeuille
Jan 30, 2013·Journal of Medical Virology·Xiu-hui YangYong Zhou
Feb 17, 2006·Médecine et maladies infectieuses·H Peigue-LafeuilleC Henquell
Apr 9, 2015·American Journal of Epidemiology·Casper RoedNiels Obel
Jul 7, 2012·Journal of Virological Methods·Romain VolleChristine Archimbaud
Oct 16, 2004·Journal of Medical Virology·Christine ArchimbaudCécile Henquell
Mar 26, 2004·Journal of Medical Virology·Pierre HausfaterBruno Riou
Dec 25, 2007·The Korean journal of laboratory medicine·Se Ran HeoEui Chong Kim
Sep 9, 2006·Journal of Clinical Laboratory Analysis·Kamal DumaidiAntonis Antoniadis
Dec 16, 2006·The Journal of General Virology·Audrey MirandJean-Luc Bailly
Dec 20, 2002·Pathologie-biologie·H Peigue-LafeuilleM Chambon
Aug 30, 2003·Archives of Pathology & Laboratory Medicine·Betty A Forbes
Dec 23, 2004·La Presse médicale·M PavicL Crevon