Enterovirus-related type 1 diabetes mellitus and antibodies to glutamic acid decarboxylase in Japan

The Journal of Infection
Hisashi KawashimaTakayuki Mori

Abstract

In order to clarify the relationship between enteroviruses and type 1 diabetes mellitus in Japan we investigated enteroviral RNA in serum from children with type 1 diabetes mellitus. We investigated enteroviral RNA in serum from children with type 1 diabetes mellitus by using highly sensitive RT-PCR. Additionally the sequences and viral loads were determined and compared with anti-coxsackie virus antibodies and anti-glutamic acid decarboxylase (GAD) antibodies. RT-PCR for enterovirus was positive in 23 (37.7%) from 61 samples. The positivity had no disparity of age, but decreased by aging after the occurrence of type 1 diabetes mellitus. The sequences of the positives were similar as those of coxsackie B4. The viral loads revealed that there was no positive patient with high titers of anti-GAD antibodies. In Japan there is some correlation with type 1 diabetes mellitus and enterovirus. The pathophysiology of type 1 diabetes mellitus seems to consist of a direct destruction by persistent coxsackie virus and the autoimmune mechanism through autoantibodies against beta-cells.

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Citations

Jan 13, 2015·Journal of Pathogens·Jana PrecechtelovaShubhada Bopegamage
Apr 29, 2010·Seminars in Immunopathology·Sisko TauriainenHeikki Hyöty
Aug 21, 2008·Journal of Medical Virology·German TapiaKjersti S Rønningen
Nov 28, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Imen BoussaidFoued Ben Hadj Slama
Apr 28, 2018·The Kaohsiung Journal of Medical Sciences·Omid Zargari SamaniAkram Sarmadi
May 21, 2011·Expert Review of Clinical Immunology·Famara SanéDidier Hober
Oct 2, 2013·Indian Journal of Endocrinology and Metabolism·Sanjay KalraAmbady Ramachandran
Jan 11, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Feliciana Real-FernándezAnna Maria Papini

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