Enterovirus replication: go with the (counter)flow

Trends in Microbiology
Jules NchoutmboubeGeorge A Belov

Abstract

All (+)RNA viruses replicate on distinct membranous domains; however, how they induce and maintain their unique lipid composition is largely unknown. Two recent studies reveal that enteroviruses harness the PI4P-cholestrol exchange cycle driven by OSBP1 protein and PI4 kinase(s), and that blocking the dynamic lipid flow inhibits virus replication.

References

Nov 11, 2011·Journal of Virology·George A BelovEllie Ehrenfeld
Jun 13, 2014·Journal of Virology·George A Belov, Elizabeth Sztul
Feb 3, 2015·Cell Reports·Jeroen R P M StratingFrank J M van Kuppeveld

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Citations

Mar 2, 2016·Biochimica Et Biophysica Acta·Bruno Mesmin, Bruno Antonny
Jan 3, 2019·ChemMedChem·Sharada Prasanna Swain, Sandeep Mohanty
Feb 24, 2017·Journal of Virology·Anabel GuedánRoberto Solari
Sep 26, 2020·Frontiers in Microbiology·Xinhong LiXiaoyue Chen
May 26, 2020·Cell Biology International·Shiva ShahmohamadnejadSeyed Mohammad Nabavi
Jul 5, 2019·Antiviral Research·Brett L RobertsAnthony W G Burgett

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