Enthalpically driven peptide stabilization by protective osmolytes

Chemical Communications : Chem Comm
Regina Politi, Daniel Harries

Abstract

We determined the added enthalpic and entropic contributions of protective osmolytes to the folding of a model peptide into its native beta-hairpin state. In contrast to entropically driven steric "crowding", this study shows that sugars and polyols can act as protective osmolytes by primarily diminishing the unfavourable enthalpic contribution to folding.

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