Entorhinal Cortex Volume Is Associated With Dual-Task Gait Cost Among Older Adults With MCI: Results From the Gait and Brain Study

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Ryota SakuraiManuel M Montero-Odasso

Abstract

Low dual-task gait performance (the slowing of gait speed while performing a demanding cognitive task) is associated with low cognitive performance and an increased risk of progression to dementia in older adults with mild cognitive impairment. However, the reason for this remains unclear. This study aimed to examine the relationship between dual-task cost and regional brain volume, focusing on the hippocampus, parahippocampal gyrus, entorhinal cortex, and motor and lateral frontal cortices in older adults with mild cognitive impairment. Forty older adults with mild cognitive impairment from the "Gait and Brain Study" were included in this study. Gait velocity was measured during single-task (ie, walking alone) and dual-task (ie, counting backwards, subtracting serial sevens, and naming animals, in addition to walking) conditions, using an electronic walkway. Regional brain volumes were derived by automated segmentation, using 3T magnetic resonance imaging. Partial rank correlation analyses demonstrated that a smaller volume of the left entorhinal cortex was associated with higher dual-task costs in counting backwards and subtracting serial sevens conditions. Subsequent logistic regression analyses demonstrated that a smaller v...Continue Reading

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Citations

Jul 20, 2019·Journal of Alzheimer's Disease : JAD·Stephanie CullenManuel Montero-Odasso
Sep 3, 2019·Journal of Alzheimer's Disease : JAD·Manuel Montero-Odasso, George Perry
Mar 13, 2019·Journal of Internal Medicine·Q TianL Ferrucci
Nov 25, 2020·Experimental Gerontology·Michelle GrayNick T Bott
Jan 26, 2021·Geriatrics & Gerontology International·Ryota SakuraiUNKNOWN Takashimadaira Study Group
Nov 15, 2020·Mechanisms of Ageing and Development·Gianmaria MancioppiFilippo Cavallo
Jun 17, 2021·Scientific Reports·Ryota SakuraiSusumu Ogawa

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