Entorhinal Neurons Exhibit Cue Locking in Rodent VR

Frontiers in Cellular Neuroscience
Giulio CasaliCaswell Barry

Abstract

The regular firing pattern exhibited by medial entorhinal (mEC) grid cells of locomoting rodents is hypothesized to provide spatial metric information relevant for navigation. The development of virtual reality (VR) for head-fixed mice confers a number of experimental advantages and has become increasingly popular as a method for investigating spatially-selective cells. Recent experiments using 1D VR linear tracks have shown that some mEC cells have multiple fields in virtual space, analogous to grid cells on real linear tracks. We recorded from the mEC as mice traversed virtual tracks featuring regularly spaced repetitive cues and identified a population of cells with multiple firing fields, resembling the regular firing of grid cells. However, further analyses indicated that many of these were not, in fact, grid cells because: (1) when recorded in the open field they did not display discrete firing fields with six-fold symmetry; and (2) in different VR environments their firing fields were found to match the spatial frequency of repetitive environmental cues. In contrast, cells identified as grid cells based on their open field firing patterns did not exhibit cue locking. In light of these results we highlight the importance ...Continue Reading

References

Sep 14, 2000·Hippocampus·Tom HartleyJohn O'Keefe
Jun 16, 2004·The Journal of General Physiology·Bruno RivardRobert U Muller
Jun 21, 2005·Nature·Torkel HaftingEdvard I Moser
May 18, 2006·Reviews in the Neurosciences·Caswell BarryNeil Burgess
Jul 22, 2006·Nature Reviews. Neuroscience·Bruce L McNaughtonMay-Britt Moser
May 9, 2007·Nature Neuroscience·Caswell BarryKathryn J Jeffery
Dec 20, 2008·Science·Trygve SolstadEdvard I Moser
Feb 21, 2009·PLoS Computational Biology·Yoram Burak, Ila R Fiete
Aug 7, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Colin LeverNeil Burgess
Oct 16, 2009·Nature·Christopher D HarveyDavid W Tank
Dec 12, 2012·Nature·Hanne StensolaEdvard I Moser
Dec 21, 2012·Proceedings of the National Academy of Sciences of the United States of America·Guifen ChenJohn O'Keefe
Feb 12, 2013·Nature·Cristina DomnisoruDavid W Tank
Feb 12, 2013·Nature Neuroscience·Christoph Schmidt-Hieber, Michael Häusser
Dec 25, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Christoph Schmidt-Hieber, Michael Häusser
May 3, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher P Burgess, Neil Burgess
Feb 13, 2015·Nature·Tor StensolaEdvard I Moser
Feb 13, 2015·Nature·Julija KrupicJohn O'Keefe
Apr 22, 2015·Neuron·Kiah HardcastleLisa M Giocomo
Apr 29, 2015·Current Biology : CB·Francis CarpenterCaswell Barry
Sep 22, 2015·Current Biology : CB·Shawn S WinterJeffrey S Taube
Aug 9, 2016·Current Biology : CB·Guifen ChenThomas Joseph Wills
Mar 2, 2018·Current Zoology·Kay Thurley, Aslı Ayaz
Mar 29, 2018·Science·Julija KrupicJohn O'Keefe
May 11, 2018·Nature·Andrea BaninoDharshan Kumaran

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.