Entropic forces drive clustering and spatial localization of influenza A M2 during viral budding

Proceedings of the National Academy of Sciences of the United States of America
Jesper J MadsenGregory A Voth

Abstract

The influenza A matrix 2 (M2) transmembrane protein facilitates virion release from the infected host cell. In particular, M2 plays a role in the induction of membrane curvature and/or in the scission process whereby the envelope is cut upon virion release. Here we show using coarse-grained computer simulations that various M2 assembly geometries emerge due to an entropic driving force, resulting in compact clusters or linearly extended aggregates as a direct consequence of the lateral membrane stresses. Conditions under which these protein assemblies will cause the lipid membrane to curve are explored, and we predict that a critical cluster size is required for this to happen. We go on to demonstrate that under the stress conditions taking place in the cellular membrane as it undergoes large-scale membrane remodeling, the M2 protein will, in principle, be able to both contribute to curvature induction and sense curvature to line up in manifolds where local membrane line tension is high. M2 is found to exhibit linactant behavior in liquid-disordered-liquid-ordered phase-separated lipid mixtures and to be excluded from the liquid-ordered phase, in near-quantitative agreement with experimental observations. Our findings support a...Continue Reading

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Citations

Jan 10, 2020·Nanoscale·Sang Young NohRebecca Notman
Jan 11, 2020·Frontiers in Cell and Developmental Biology·Mikhail A ZhukovskyCarmen Valente
Mar 13, 2020·Nature Communications·Alvin YuGregory A Voth
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Mar 11, 2020·Chemical Science·P H Erik HammingJurriaan Huskens
Jun 18, 2021·Nature Communications·Senthil ArumugamLudger Johannes
Jun 19, 2021·The Journal of Physical Chemistry. B·Siyoung Kim, Gregory A Voth
Jul 10, 2021·The Journal of Chemical Physics·Anvy Moly TomChangbong Hyeon
Aug 8, 2021·Cells·Etori Aguiar MoreiraPatrick Matthias
Jul 23, 2020·Nano Letters·Guolong ZhuLi-Tang Yan
Jan 10, 2019·Chemical Reviews·Siewert J MarrinkMark S P Sansom
Jul 10, 2020·The Journal of Physical Chemistry. B·Agnieszka MartynaJeremy S Rossman
Jun 15, 2019·ACS Nano·Guillermo Moreno-PescadorPoul Martin Bendix
Sep 1, 2021·Current Opinion in Virology·Peter Eugene JonesJodi A Hadden-Perilla
Sep 21, 2021·Faraday Discussions·Viviana Monje-Galvan, Gregory A Voth
Oct 30, 2021·Journal of Chemical Information and Modeling·Dimitrios KolokourisAntonios Kolocouris
Nov 6, 2021·Scientific Reports·Lionel GalibertKari J Airenne

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