PMID: 11606803Oct 19, 2001Paper

Entry, half-life, and desferrioxamine-accelerated clearance of brain aluminum after a single (26)Al exposure

Toxicological Sciences : an Official Journal of the Society of Toxicology
Robert A YokelP J McNamara

Abstract

The objectives of our study were to estimate the percentage of aluminum (Al) that enters the brain, the half-life of brain Al, and the ability of an Al chelator to reduce brain Al. Rats received an iv infusion of Al transferrin, the primary Al species in plasma, or Al citrate, the predominant small molecular weight Al species in plasma. The infusion contained approximately 0.2-0.3 nCi (0.4-0.6 nmol) (26)Al, enabling the study of Al distribution into and retention by the brain at physiological Al concentrations. Some Al transferrin-infused rats received ip injections of the Al chelator desferrioxamine (DFO), 0.15 mmol/kg, three times weekly. The others received saline injections. The rats were euthanized from 4 hr to 4 days (Al citrate) or 256 days (Al transferrin) later. Brain (26)Al was determined by accelerator mass spectrometry. Peak brain (26)Al concentration was approximately 0.005% of the (26)Al dose in each gram of brain, irrespective of Al species administered. In the absence of DFO treatments, brain (26)Al concentration decreased with a half-life of approximately 150 days. The brain Al half-life in the DFO-treated rats was approximately 55 days. The results show a small fraction of Al in blood enters the brain, where i...Continue Reading

References

Jun 1, 1979·Neurology·J R McDermottH M Wisniewski
Sep 1, 1978·The American Journal of Physiology·K OhnoS I Rapoport
Jan 22, 1976·The New England Journal of Medicine·A C AlfreyW D Kaehny
Jun 1, 1991·Lancet·D R Crapper McLachlanD F Andrews
Feb 1, 1991·British Journal of Industrial Medicine·K G LjunggrenB Sjögren
Jun 1, 1989·Toxicology and Applied Pharmacology·R A Yokel, P J McNamara
Nov 1, 1989·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·R W JacobsA B Scheibel
Mar 1, 1986·Environmental Health Perspectives·P O Ganrot
Oct 1, 1986·Journal of Inorganic Biochemistry·R B Martin
Jan 1, 1984·Neurobiology of Aging·W R MarkesberyT I Hossain
Jul 1, 1980·The American Journal of Clinical Nutrition·A C AlfreyP Craswell
Oct 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J L Greger, G M Radzanowski
Mar 1, 1995·Human & Experimental Toxicology·N D PriestA J Warner
Jan 1, 1995·Biological Trace Element Research·M D ZapateroA Marro
Oct 1, 1994·Proceedings of the Society for Experimental Biology and Medicine·J L GregerG G MacNeil
Aug 30, 1996·Journal of Toxicology and Environmental Health·R A YokelJ Savory
Jan 1, 1997·Annual Review of Medicine·D A Bushinsky
Oct 17, 1998·Toxicology and Applied Pharmacology·C B DobsonR F Itzhaki
Apr 27, 2001·Pharmacology & Toxicology·R A Yokel, P J McNamara

❮ Previous
Next ❯

Citations

Aug 1, 2008·Archives of Toxicology·Sandra V VerstraetenPatricia I Oteiza
Jan 29, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ali Asghar MoshtaghieMohsen Ani
Jan 7, 2010·Cell Biology and Toxicology·Ana I CalejoPaula P Gonçalves
Nov 10, 2013·Journal of Inorganic Biochemistry·Leonardo TosoZbigniew Szewczuk
Mar 31, 2004·Molecular Aspects of Medicine·Patricia I OteizaSandra V Verstraeten
Dec 22, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Daniel KrewskiVirginie Rondeau
Nov 12, 2002·Environmental Health Perspectives·Robert A Yokel
Oct 26, 2012·Analytical and Bioanalytical Chemistry·Guido CrisponiAndrea Tapparo
Jun 6, 2006·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Marjorie S FriesenRobert D Gair
Jun 4, 2014·Vaccine·Matthias F Kramer, Matthew D Heath
Oct 1, 2016·Biological Trace Element Research·Agata Miska-SchrammMałgorzata Kruczek
Apr 20, 2012·Critical Reviews in Toxicology·Calvin C WillhiteClifton J McLellan
Nov 7, 2007·Human & Experimental Toxicology·Sunyoun KimKisok Kim
Feb 27, 2017·Regulatory Toxicology and Pharmacology : RTP·Karin WeisserWilhelm Huisinga
Aug 14, 2015·International Journal of Environmental Research and Public Health·J Marvin Herndon
Feb 12, 2005·Journal of Mass Spectrometry : JMS·Magnus PalmbladJohn S Vogel
Oct 12, 2018·Archives of Toxicology·Karin WeisserBrigitte Keller-Stanislawski
Sep 16, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Virgília S SilvaPaula P Gonçalves
Sep 28, 2012·Critical Reviews in Toxicology·Vesa Riihimäki, Antero Aitio
Aug 21, 2013·Journal of Food Science·Carmen Cabrera-Vique, Marta Mesías
Sep 2, 2020·Critical Reviews in Toxicology·Robert A Yokel
Aug 1, 2019·Archives of Toxicology·Karine P ReichertVera M M Morsch
Feb 16, 2020·Scientific Reports·Benjamin C KrauseAndreas Luch
May 2, 2021·International Journal of Pharmaceutics·Jean-Pierre GoulléLiliane Grangeot-Keros
Aug 15, 2021·Archives of Toxicology·Christoph HetheyWilhelm Huisinga

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.