Entry into a new class of potent proteasome inhibitors having high antiproliferative activity by structure-based design

Journal of Medicinal Chemistry
Pascal FuretCarlos García-Echeverría

Abstract

Proteasome inhibition is a therapeutic concept of current interest in anticancer research. We report here the design, synthesis, and biological characterization of prototypes of a new class of noncovalent proteasome inhibitors showing high activity in biochemical and cellular assays.

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Citations

Sep 21, 2010·Cell Biology and Toxicology·Khandan KeyomarsiTuyen N Bui
Jun 16, 2012·Journal of the American Chemical Society·Donghui WeiChang-Guo Zhan
Apr 4, 2013·Journal of Medicinal Chemistry·Sevil OzcanSaïd M Sebti
Dec 11, 2013·European Journal of Medicinal Chemistry·Makoto HasegawaTamio Mizukami
Mar 1, 2006·International Journal of Peptide Research and Therapeutics·Carlos García-Echeverría
Mar 24, 2012·European Journal of Medicinal Chemistry·Xavier MaréchalJoëlle Vidal
Jan 8, 2016·Annual Review of Pharmacology and Toxicology·Paweł Śledź, Wolfgang Baumeister
Sep 4, 2010·Journal of Peptide Science : an Official Publication of the European Peptide Society·Anna BaldisserottoRoberto Tomatis
Mar 4, 2014·Medicinal Research Reviews·Nicola MicaleMaria Zappalà
Mar 29, 2014·Journal of Peptide Science : an Official Publication of the European Peptide Society·Mauro MarastoniRiccardo Gavioli
Jul 12, 2005·Current Opinion in Chemical Biology·Shawn P WilliamsKenneth H Pearce
Mar 3, 2012·Journal of Enzyme Inhibition and Medicinal Chemistry·Christian FranceschiniMauro Marastoni
Jul 10, 2010·Biochimie·Geoffroy de Bettignies, Olivier Coux
Jan 31, 2012·Chemistry & Biology·Alexei F KisselevHerman S Overkleeft
Nov 13, 2007·European Journal of Medicinal Chemistry·Anna BaldisserottoRoberto Tomatis
Dec 2, 2008·Bioorganic & Medicinal Chemistry Letters·Lucia FormicolaSandrine Ongeri
Jul 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Romina A GuedesRita C Guedes
Jan 7, 2019·European Journal of Medicinal Chemistry·Jianjun YuYubo Zhou
Nov 19, 2009·Journal of Medicinal Chemistry·Nicolas BasseMichèle Reboud-Ravaux
Oct 22, 2014·Journal of Medicinal Chemistry·Audrey DesvergneJoëlle Vidal
May 22, 2007·Journal of Medicinal Chemistry·Nicolas BasseJoëlle Vidal
Jul 22, 2005·Journal of Medicinal Chemistry·Mauro MarastoniRoberto Tomatis

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