Entry of malaria parasites into resealed ghosts of human and simian erythrocytes

British Journal of Haematology
A R DluzewskiW B Gratzer

Abstract

Whereas "white' ghosts, conventionally prepared by hypotonic lysis and washing are resistant to invasion by malaria parasites, cells lysed at high haematocrit and resealed without separating the membranes from the cytosol are invaded with high efficiency (not less than one-third the frequency of intact cells). Similar results were obtained with human and monkey cells, exposed respectively to Plasmodium falciparum and P. knowlesi. Microspectrophotometry of individual cells was used to ascertain the the susceptibility to invasion of lysed, resealed cells was not related to its haemoglobin content.

References

Jun 12, 1976·Lancet·G PasvolH M Gilles
Feb 1, 1978·Annals of Tropical Medicine and Parasitology·G PasvolJ Brown
Nov 14, 1979·Biochemical and Biophysical Research Communications·U SprandelR A Chalmers
Jun 15, 1978·The Biochemical Journal·W J Mawby, J B Findlay
Aug 20, 1976·Science·W Trager, J B Jensen
Feb 15, 1980·Biochimica Et Biophysica Acta·E KansuS K Ballas
Jan 1, 1963·Archives of Biochemistry and Biophysics·J T DODGED J HANAHAN

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Citations

Oct 1, 1983·Molecular and Biochemical Parasitology·A R DluzewskiW B Gratzer
Dec 30, 2006·PLoS Medicine·Sean C MurphyKasturi Haldar
Feb 20, 1992·Journal of Molecular Biology·A E SchofieldR J Wilson
Jan 1, 1988·Critical Reviews in Oncology/hematology·G H Mitchell, L H Bannister
Mar 29, 2014·PLoS Neglected Tropical Diseases·Catherine L MoyesSimon I Hay
Jun 1, 1985·Parasitology·S M Mutetwa, E R James

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