PMID: 7525854Dec 1, 1994Paper

Entry of naive CD4 T cells into peripheral lymph nodes requires L-selectin

The Journal of Experimental Medicine
L M BradleyS L Swain

Abstract

Binding of L-selectin expressed on lymphocytes to carbohydrate ligand(s) on lymph node high endothelial venules is thought to initiate lymphocyte extravasation from blood to lymph during recirculation and localization to sites of antigen (Ag) exposure. Previous studies have shown that treatment of lymphocytes with antibody to L-selectin (MEL-14) ablates trafficking to peripheral lymph nodes (PLN). In mice, naive but not memory CD4 cells express L-selectin. To examine the role of L-selectin in helper T cell migration, we studied the effects of in vivo administration of MEL-14 on CD4 cell responses. Systemic exposure of mice to MEL-14 depleted CD4 cells expressing a naive phenotype (CD45RBhi, CD44lo) from PLN but not from spleen. The majority of residual lymph node CD4 cells exhibited the reciprocal, memory phenotype (CD45RBlo, CD44hi). MEL-14 treatment prevented priming of naive CD4 cells for proliferation and cytokine production (IL-2 and IL-4) to keyhole limpet hemocyanin in PLN draining the site of Ag injection, but not in the spleen. The results suggest that naive cells were not depleted, but rather diverted to other sites where priming occurred. The data demonstrate that L-selectin mediates extravasation of naive CD4 cells ...Continue Reading

References

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Citations

May 6, 1999·European Journal of Immunology·F A SymonA J Wardlaw
Oct 30, 1999·European Journal of Immunology·L M BradleyS R Watson
Apr 24, 2010·Cancer Immunology, Immunotherapy : CII·Suzanne Ostrand-Rosenberg
Nov 5, 2013·Veterinary Immunology and Immunopathology·Weidong ZhangMasahiro Yasuda
Sep 19, 1998·Journal of the Neurological Sciences·J J ArchelosH P Hartung
Dec 16, 1998·The Journal of Allergy and Clinical Immunology·A Sánchez-SeguraC Rodríguez
Jan 16, 2003·Immunology Letters·Allan Randrup ThomsenJan Pravsgaard Christensen
Jun 1, 1996·Current Opinion in Immunology·L M Bradley, S R Watson
Feb 1, 1996·The Journal of Experimental Medicine·J XuR A Flavell
Sep 20, 2000·The Journal of Experimental Medicine·T BrabbJ Goverman
Oct 9, 2002·The Journal of Experimental Medicine·Eulogia RománSusan L Swain
Mar 30, 2005·The Journal of Experimental Medicine·Dawn M Jelley-GibbsSusan L Swain
Jul 29, 2004·Viral Immunology·Susan L SwainDavid L Woodland
Apr 1, 1996·Immunological Reviews·P C DohertyR A Tripp
Apr 1, 1997·Immunological Reviews·R M SteinmanK Inaba
Jan 7, 1998·Immunological Reviews·P C DohertyP G Stevenson
May 23, 1998·Annual Review of Immunology·R W DuttonS L Swain
Nov 21, 1998·Cell Adhesion and Communication·S R Watson, L M Bradley
Jun 21, 2011·Advanced Drug Delivery Reviews·Ivy Pal, Joshua D Ramsey
Nov 30, 2005·The American Journal of Pathology·Paul R ManganCasey T Weaver
Aug 7, 2009·European Journal of Immunology·Melanie R Gubbels BuppStanford L Peng
Feb 1, 1996·The Journal of Laboratory and Clinical Medicine·B Schleiffenbaum, J Fehr
Mar 24, 2000·Brain, Behavior, and Immunity·J M DoppJ L Fahey

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