Entry route of HCMV into endothelial cells

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Christian Sinzger

Abstract

Human cytomegalovirus (HCMV) is generally assumed to enter its target cells by direct fusion at the plasma membrane while sequestration and lysis of viral particles within endocytic vesicles has been suggested as an abortive entry pathway of fibroblast-adapted HCMV strains in endothelial cells. However, the finding that virions of a highly endotheliotropic strain are also found within endocytic vesicles at 10min after penetration together with the fact that the majority of these particles is translocated towards the nucleus indicates that endocytosis can be an effective entry route for HCMV in endothelial cells. HCMV-containing vesicles resemble endocytic vesicles reported for other herpesviruses with regard to size and structure suggesting a similar entry route for various herpesviruses in endocytically active cells.

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Citations

Jan 21, 2011·PLoS Pathogens·Laura ScrivanoBarbara Adler
Nov 11, 2011·PLoS Pathogens·Kasinath ViswanathanKlaus Früh
Jul 20, 2010·Immunotherapy·Raymund R Razonable
Jul 25, 2009·Expert Review of Vaccines·Wolfgang Herr, Bodo Plachter
Jan 18, 2013·Journal of Digestive Diseases·Meng XueJian Min Si
Jun 4, 2014·Reviews in Medical Virology·Laura Hertel
Dec 10, 2015·Traffic·Stefanie HetzeneckerMagdalena Anna Krzyzaniak
May 19, 2010·The Journal of General Virology·Derrick J DarganAndrew J Davison
Jun 1, 2016·Frontiers in Microbiology·Anna LuganiniGiorgio Gribaudo
Apr 15, 2017·Biochemical Society Transactions·Laura A FastLuise Florin
Jul 4, 2012·Viruses·Roselyn J EisenbergGary H Cohen
May 10, 2017·Frontiers in Immunology·Linda GroscheChristiane S Heilingloh

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