Environment-induced lentigines: formation of solar lentigines beyond ultraviolet radiation

Experimental Dermatology
Motoki NakamuraJean Krutmann

Abstract

There is no doubt that ultraviolet radiation (UVR) contributes to the generation of acquired lentigines in human skin, as indicated by the term solar lentigo. A growing number of recent epidemiological and mechanistic studies, however, strongly suggest that in addition to UVR, other environmental factors contribute to lentigines' formation as well. We therefore here introduce the term 'environment-induced lentigo' (EIL) to refer to acquired pigment spots of human skin. In this view point, we (i) summarize the existing evidence to support a role of environmental toxicants other than UVR in the pathogenesis of EILs, (ii) we argue that activation of aryl hydrocarbon receptor (AHR) signalling by UVR and environmental toxicants is critically involved in triggering and sustaining a crosstalk between melanocytes, keratinocytes and fibroblasts, which then causes the development and persistence of EILs in human skin, and (iii) we discuss clinical implications for the prevention and treatment of EILs resulting from this concept.

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Citations

Jan 16, 2016·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·J KrutmannS Grether-Beck
Apr 24, 2016·The Journal of Investigative Dermatology·Anne Lynn S Chang
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Mar 27, 2018·Journal of Cosmetic Dermatology·David McDanielGiuseppe Valacchi
Feb 18, 2017·The British Journal of Dermatology·R GoorochurnC Le Roy
Mar 16, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·T PasseronA Badawi
Feb 26, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·J H ParkJ H Lee
Jan 14, 2020·Current Environmental Health Reports·Tamara Schikowski, Anke Hüls
May 24, 2020·Antioxidants & Redox Signaling·Giuseppe ValacchiPablo Evelson
Jul 18, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·B M R AppenzellerL Aguilar
Aug 17, 2017·Journal of Receptor and Signal Transduction Research·Saeed MohammadiYaghoub Yazdani
Sep 15, 2018·International Journal of Molecular Sciences·Seo-Yeon ParkHei Sung Kim
Jan 11, 2019·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·T Schikowski, J Krutmann
Jan 8, 2016·Experimental Dermatology·Ranesha GoorochurnPhilippe Humbert
Aug 8, 2021·International Journal of Molecular Sciences·Enkhmend Enkhtaivan, Chang Hoon Lee
Aug 20, 2021·Photodermatology, Photoimmunology & Photomedicine·Soomin KimJu Hee Lee

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