PMID: 2498933Jan 1, 1989Paper

Environment-specific tolerance to nicotine

Psychopharmacology
L H EpsteinR L Stiller

Abstract

Research has shown that tolerance to the behavioral effects of numerous drugs is mediated by learning. The present study was designed to test whether animals develop tolerance to the antinociceptive effects of nicotine, and whether these effects are also learned. Rats were given dally injections of nicotine in the same environment. After each injection, the latency of tail withdrawal from a hot water bath was measured. This was continued until they were tolerant to the drug: i.e., their response latencies did not differ from animals repeatedly given saline. The role of learning in nicotine tolerance was assessed by changing the environment in which they received nicotine on the day after tolerance was achieved. When the drug environment was changed, the animals recovered the full dose effect of nicotine on tail-flick latencies. These results show that tolerance develops to nicotine's antinociceptive effects, and that this tolerance also may be influenced by learning.

References

Jul 1, 1975·Journal of Comparative and Physiological Psychology·S Siegel
Jul 1, 1987·Pharmacology, Biochemistry, and Behavior·M J MarksA C Collins
Dec 16, 1986·European Journal of Pharmacology·M D AcetoJ R Hinson
Feb 1, 1983·British Journal of Pharmacology·P B Clarke, R Kumar
Jan 1, 1984·Addictive Behaviors·O F PomerleauJ B Fertig

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Citations

Jan 1, 1989·Psychopharmacology·A R CaggiulaR Stiller
Jan 1, 1992·Psychopharmacology·E A GrunA C Collins
Jul 1, 1990·Pharmacology, Biochemistry, and Behavior·J B Smith
Sep 1, 1991·Pharmacology, Biochemistry, and Behavior·A R CaggiulaR Stiller
May 1, 1991·Pharmacology, Biochemistry, and Behavior·L H EpsteinJ A Smith
Jun 1, 1993·Pharmacology, Biochemistry, and Behavior·K A PerkinsR G Jacob
May 1, 1992·Progress in Neuro-psychopharmacology & Biological Psychiatry·H Frances, C Monier
Jan 16, 2003·Physiology & Behavior·Anthony R CaggiulaAlan F Sved
Jun 11, 1998·Psychoneuroendocrinology·A R CaggiulaK A Perkins
Nov 9, 2006·Learning & Behavior·Julian L AzorlosaJames J McConnell
Jan 18, 2005·Behavioral and Cognitive Neuroscience Reviews·Rick A Bevins, Matthew I Palmatier

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