Environmental and dietary risk factors for infantile atopic eczema among a Slovak birth cohort

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Anne L DunlopScott J N McNabb

Abstract

Infantile atopic eczema (AE) is a risk marker for future asthma. This study assesses the contribution of modifiable exposures to infantile AE. If modifiable exposures contribute substantially to infantile AE, its prevention might be a sensible approach to asthma prevention. Pregnant women (n = 1978) were systematically recruited from maternity hospitals of the Slovak Republic; their birthed cohort of 1990 children were prospectively followed for 1 yr. Children's exposures to selected environmental and dietary factors were assessed via maternal questionnaires administered at delivery and 1 yr of age. A child was considered to have AE, based on physical examination (SCORAD index >2) or mother's report of a previous physician diagnosis. Multivariate logistic regression was used to calculate adjusted odds ratios and percent total regression scores (TRS) for each variable. At 1 yr of age 1326 (67%) of the children remained in the cohort and 207 (15.6%) developed AE. Various modifiable environmental and dietary exposures increased the likelihood of AE (ownership of cats; consumption of infant formula, eggs, and fish) while others decreased the likelihood of AE (ownership of livestock; exclusive breast feeding for > or =4 months). Ove...Continue Reading

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Citations

Jul 21, 2015·Acta Paediatrica·C J LodgeS C Dharmage
Mar 19, 2008·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Bénédicte ClarisseIsabelle Momas
May 29, 2013·The Journal of Allergy and Clinical Immunology·Claudio PelucchiLiliane Chatenoud
Jun 24, 2018·European Journal of Pediatrics·Marketa VrbovaVojtech Thon
Jul 7, 2020·EFSA Journal·UNKNOWN EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA)Dominique Turck
Jan 25, 2021·AAPS PharmSciTech·Khushali ParekhAmirali Popat

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