Environmental and genetic determinants of intima-media thickness of the carotid artery

Clinical and Experimental Pharmacology & Physiology
F ZannadS Visvikis

Abstract

1. The aim of the present study was to investigate carotid intima-media thickness (CIMT) in relation to anthropometric, environmental and genetic factors, as well as cholesterol and blood pressure levels. 2. The study sample was composed of 89 families, with no documented cardiovascular disease, consisting of 369 subjects (aged from 10 to 54 years) from the Stanislas cohort. 3. Carotid intima-media thickness was measured by B-mode ultrasonography. Fifteen genetic markers, including genes involved in lipid metabolism, the regulation of blood pressure, thrombosis, platelet function and endothelial cell adhesion, were studied by multiplex assay. 4. The effects of gender, age, smoking, alcohol, body mass index, cholesterol, blood pressure and genetic factors were studied using ANOVA and bivariate and regression analyses. 5. Segregation analysis was also performed to estimate the contribution of genetic and environmental factors to CIMT variability. 6. Carotid intima-media thickness values were not affected by age or by gender up to 18 years of age. Thereafter, CIMT values increased sharply in men and remained significantly higher than in women. 7. Approximately 30% of CIMT variability was attributable to genetic factors. Associatio...Continue Reading

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Citations

Dec 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Paula GrönroosTerho Lehtimäki
Dec 17, 2009·The Journal of Pediatrics·Steven D MittelmanVicente Gilsanz
Dec 6, 2005·Metabolism: Clinical and Experimental·Thomas ReinehrRanier Wunsch
Oct 29, 2005·The American Journal of Cardiology·Anna Kablak-ZiembickaAndrzej Sokolowski
Sep 8, 2010·Clinical Science·Donald R DengelAlan R Sinaiko
Mar 15, 2006·Journal of Hypertension·Riccardo SarzaniAlessandro Rappelli
May 7, 2020·Journal of the American Heart Association·Justin R RyderElaine M Urbina

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