Environmental and Genetic Factors Explain Differences in Intraocular Scattering

Investigative Ophthalmology & Visual Science
Antonio BenitoPablo Artal

Abstract

To study the relative impact of genetic and environmental factors on the variability of intraocular scattering within a classical twin study. A total of 64 twin pairs, 32 monozygotic (MZ) (mean age: 54.9 ± 6.3 years) and 32 dizygotic (DZ) (mean age: 56.4 ± 7.0 years), were measured after a complete ophthalmologic exam had been performed to exclude all ocular pathologies that increase intraocular scatter as cataracts. Intraocular scattering was evaluated by using two different techniques based on a straylight parameter log(S) estimation: a compact optical instrument based in the principle of optical integration and a psychophysical measurement. Intraclass correlation coefficients (ICC) were used as descriptive statistics of twin resemblance, and genetic models were fitted to estimate heritability. No statistically significant difference was found for MZ and DZ groups for age (P = 0.203), best-corrected visual acuity (P = 0.626), cataract gradation (P = 0.701), sex (P = 0.941), optical log(S) (P = 0.386), or psychophysical log(S) (P = 0.568), with only a minor difference in equivalent sphere (P = 0.008). Intraclass correlation coefficients between siblings were similar for scatter parameters: 0.676 in MZ and 0.471 in DZ twins for...Continue Reading

Citations

Sep 17, 2019·Annual Review of Vision Science·Alan Shiels, J Fielding Hejtmancik
May 20, 2020·Scientific Reports·Dibyendu PustiPablo Artal
Jun 11, 2021·Scientific Reports·Dibyendu PustiPablo Artal
Jun 15, 2021·Experimental Eye Research·Alan Shiels, J Fielding Hejtmancik
Aug 12, 2021·Translational Vision Science & Technology·Juan TaberneroShahina Pardhan

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