Environmental and Genetic Factors in Autism Spectrum Disorders: Special Emphasis on Data from Arabian Studies

International Journal of Environmental Research and Public Health
Noor B AlmandilJ Francis Borgio

Abstract

One of the most common neurodevelopmental disorders worldwide is autism spectrum disorder (ASD), which is characterized by language delay, impaired communication interactions, and repetitive patterns of behavior caused by environmental and genetic factors. This review aims to provide a comprehensive survey of recently published literature on ASD and especially novel insights into excitatory synaptic transmission. Even though numerous genes have been discovered that play roles in ASD, a good understanding of the pathophysiologic process of ASD is still lacking. The protein⁻protein interactions between the products of NLGN, SHANK, and NRXN synaptic genes indicate that the dysfunction in synaptic plasticity could be one reason for the development of ASD. Designing more accurate diagnostic tests for the early diagnosis of ASD would improve treatment strategies and could enhance the appropriate monitoring of prognosis. This comprehensive review describes the psychotropic and antiepileptic drugs that are currently available as effective pharmacological treatments and provides in-depth knowledge on the concepts related to clinical, diagnostic, therapeutic, and genetic perspectives of ASD. An increase in the prevalence of ASD in Gulf C...Continue Reading

References

Oct 1, 1990·Journal of Child Neurology·R Nass, D Petrucha
Nov 1, 1983·Neuropediatrics·C Gillberg, H Schaumann
Mar 1, 1984·Journal of Autism and Developmental Disorders·J KomotoJ Hirata
Feb 1, 1993·Developmental Medicine and Child Neurology·T DeonnaG Innocenti
Jan 1, 1995·Psychological Medicine·A BaileyM Rutter
Feb 1, 1994·Archives of Pediatrics & Adolescent Medicine·A V Plioplys
Aug 1, 1997·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·J A Childs, J L Blair
Mar 31, 1998·Journal of the American Academy of Child and Adolescent Psychiatry·J DamoreL Brody
Oct 6, 2001·Pediatric Neurology·A Di Martino, R F Tuchman
Mar 29, 2002·Molecular Psychiatry·S JamainUNKNOWN Paris Autism Research International Sibpair (PARIS) Study
Nov 8, 2002·The New England Journal of Medicine·Kreesten Meldgaard MadsenMads Melbye
Aug 9, 2003·Science·V A A JansenC J Rhodes
Jan 24, 2004·BMJ : British Medical Journal·F Edward Yazbak
Apr 27, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·J L McCauleyJ S Sutcliffe
Dec 13, 2005·Trends in Neurosciences·Camin Dean, Thomas Dresbach
Sep 20, 2006·Neuron·Frédérique VaroqueauxNils Brose
Jan 25, 2007·Journal of Tropical Pediatrics·Valsamma EapenFeisal Yunis
Feb 27, 2007·Nature Genetics·UNKNOWN Autism Genome Project ConsortiumKacie J Meyer
Mar 17, 2007·Science·Jonathan SebatMichael Wigler
May 16, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Christa Lese MartinDaniel H Geschwind
Oct 31, 2007·Pediatrics·Chris Plauché JohnsonUNKNOWN American Academy of Pediatrics Council on Children With Disabilities
Jan 9, 2008·American Journal of Human Genetics·Maricela AlarcónDaniel H Geschwind
Jan 9, 2008·American Journal of Human Genetics·Betul BakkalogluMatthew W State
Apr 17, 2008·Nature Reviews. Genetics·Brett S Abrahams, Daniel H Geschwind
Aug 30, 2008·Journal of Medical Genetics·C Lintas, A M Persico
May 1, 2009·Nature·Joseph T GlessnerHakon Hakonarson
May 22, 2009·Annals of Human Genetics·Deqiong MaMargaret A Pericak-Vance
Jun 23, 2009·Transcultural Psychiatry·Saleh M Al-SalehiMohammad Ghaziuddin
Oct 9, 2009·Nature·Lauren A WeissAravinda Chakravarti
Jan 12, 2010·Developmental Medicine and Child Neurology·Ahmet O Caglayan
Feb 12, 2010·Journal of Intellectual Disability Research : JIDR·A Dabrowska, E Pisula
Jul 14, 2010·Annals of Saudi Medicine·Hadeel FarasLee Tidmarsh
Jul 21, 2010·Journal of the American Academy of Child and Adolescent Psychiatry·Ellen J Hoffman, Matthew W State
Jul 29, 2010·Human Molecular Genetics·Richard AnneyJoachim Hallmayer
Sep 3, 2010·Journal of Autism and Developmental Disorders·Yahya M Al-FarsiMostafa I Waly
Aug 23, 2011·Trends in Cognitive Sciences·Daniel H Geschwind
Nov 18, 2011·Journal of Autism and Developmental Disorders·Susan G McGrewJeremy Veenstra-Vanderweele

❮ Previous
Next ❯

Citations

Jan 5, 2020·Metabolic Brain Disease·Mohammad TaheriSoudeh Ghafouri-Fard
Sep 19, 2019·International Journal of Environmental Research and Public Health·Anna Strunecka, Otakar Strunecky
May 30, 2020·Molecular Neurobiology·B ToczylowskaJ W Lazarewicz
Jan 5, 2021·Journal of Autism and Developmental Disorders·Michelle T SiuRosanna Weksberg
Apr 3, 2021·Research in Developmental Disabilities·Mona Tawakkul Ebrahim, Abdulaziz Abdullah Alothman
May 1, 2021·International Journal of Environmental Research and Public Health·Wadzanai ManjeeseThabisile Mpofana
Aug 6, 2021·International Journal of Pediatrics & Adolescent Medicine·Moon Fai ChanSamir Al-Adawi
Aug 11, 2021·Clinical Genetics·Sirine SalehAisha Al Shamsi

❮ Previous
Next ❯

Methods Mentioned

BETA
chromosomal aberrations

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Related Papers

Frontiers in Cellular Neuroscience
Shiqi GuangJing Peng
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
Longkai HeYaping Tang
Neuroscience and Biobehavioral Reviews
Julien FregeacLam Son Nguyen
Journal of Clinical Psychopharmacology
Theoharis C Theoharides, Shahrzad Asadi
© 2022 Meta ULC. All rights reserved