Environmental and genetic risk factors for endometrial carcinoma

Bulletin du cancer
Claire SénéchalBruno Buecher

Abstract

In France, endometrial cancer is at the first rank of gynecological cancers for cancer incidence, before ovarian and cervical cancers. In fact, the number of incident cases has been estimated to 7275 for the year 2012; the number of death due to endometrial cancer to 2025. This cancer is hormone-dependent and endogenous (reproductive factors) or exogenous (oral combined contraceptives, hormone replacement therapy) causes of exposition to estrogens are the major environmental risk factors for both types of endometrial cancers: type I or well-differentiated endometrioid adenocarcinomas; and type II including all other histological types: papillary serous adenocarcinomas, clear cell adenocarcinomas and carcinosarcomas, also known as malignant mixed Mullerian tumor, MMMT. Obesity, diabetes mellitus and adjuvant treatment of breast cancer with tamoxifen are also associated with an increased risk of endometrial cancer. Genetic factors may also be implicated in the pathogenesis of endometrial cancer either as "minor genetic factors" (susceptibility factors), which remain largely unknown and are responsible for the increased observed risk in relatives of women affected with endometrial cancer; or as major genetic factors responsible fo...Continue Reading

References

Apr 24, 1999·Obstetrics and Gynecology·A M WeberM R Piedmonte
Nov 11, 2006·International Journal of Cancer. Journal International Du Cancer·Laura Renkonen-SinisaloHeikki J Järvinen
Oct 11, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karen H LuRussell R Broaddus
Oct 24, 2007·Gynecologic Oncology·Johnathan M LancasterUNKNOWN Society of Gynecologic Oncologists Education Committee
Nov 13, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shannon N WestinRussell R Broaddus
Nov 20, 2009·International Journal of Cancer. Journal International Du Cancer·Laure DossusElio Riboli
Jun 7, 2011·JAMA : the Journal of the American Medical Association·Valérie BonadonaUNKNOWN French Cancer Genetics Network
Mar 28, 2012·Gynecologic Oncology·Nan MuFengxia Xue
Mar 27, 2013·Human Molecular Genetics·David N ChurchIan P M Tomlinson
Jun 5, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Veronica Wendy SetiawanPamela L Horn-Ross
Jul 3, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J BalmañaUNKNOWN ESMO Guidelines Working Group
Dec 10, 2013·The Lancet Oncology·Roberta De AngelisUNKNOWN EUROCARE-5 Working Group
Mar 13, 2014·Revue D'épidémiologie Et De Santé Publique·F Binder-FoucardUNKNOWN French network of cancer registries (Francim)
Apr 1, 2014·Gynecologic Oncology·Kristy K WardSteven C Plaxe
May 20, 2014·Familial Cancer·Ayelet ShaiSteven A Narod
May 29, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harold J BursteinJennifer J Griggs
Jul 9, 2014·Obstetrics and Gynecology·Tuuli SoiniEero Pukkala
Jul 11, 2014·American Journal of Epidemiology·Agnès FournierNathalie Chabbert-Buffet

❮ Previous
Next ❯

Citations

May 6, 2019·Journal of Cellular Biochemistry·Jinhui LiuWenjun Cheng
Mar 25, 2017·International Journal of Oncology·Ya-Sian ChangJan-Gowth Chang
Jan 19, 2020·Gynécologie, Obstétrique, Fertilité & Sénologie·A FoulonR Fauvet

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinosarcoma

Carcinosarcoma is a malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. Discover the latest research on carcinosarcoma here.

Adenocarcinoma, Clear Cell

Clear Cell Adenocarcinoma is a tumor that arises in the female genital tract and is characterized by cells that appear clear under the microscope. Discover the latest research here.