Environmental biodiversity, human microbiota, and allergy are interrelated.

Proceedings of the National Academy of Sciences of the United States of America
Ilkka HanskiTari Haahtela

Abstract

Rapidly declining biodiversity may be a contributing factor to another global megatrend--the rapidly increasing prevalence of allergies and other chronic inflammatory diseases among urban populations worldwide. According to the "biodiversity hypothesis," reduced contact of people with natural environmental features and biodiversity may adversely affect the human commensal microbiota and its immunomodulatory capacity. Analyzing atopic sensitization (i.e., allergic disposition) in a random sample of adolescents living in a heterogeneous region of 100 × 150 km, we show that environmental biodiversity in the surroundings of the study subjects' homes influenced the composition of the bacterial classes on their skin. Compared with healthy individuals, atopic individuals had lower environmental biodiversity in the surroundings of their homes and significantly lower generic diversity of gammaproteobacteria on their skin. The functional role of the gram-negative gammaproteobacteria is supported by in vitro measurements of expression of IL-10, a key anti-inflammatory cytokine in immunologic tolerance, in peripheral blood mononuclear cells. In healthy, but not in atopic, individuals, IL-10 expression was positively correlated with the abu...Continue Reading

Associated Clinical Trials

Jan 8, 2013·Alejandro E. Macias, Alejandro E. Macias

References

Nov 18, 1989·BMJ : British Medical Journal·D P Strachan
Aug 10, 2001·The Journal of Allergy and Clinical Immunology·S H ChoD Y Leung
Mar 22, 2002·Nature Reviews. Immunology·M Wills-KarpC L Karp
Sep 20, 2002·The New England Journal of Medicine·Jean-Francois Bach
May 27, 2003·Nature Reviews. Immunology·Christina A Herrick, Kim Bottomly
Jan 3, 2006·The Journal of Allergy and Clinical Immunology·Leena von HertzenTari Haahtela
May 8, 2007·The Journal of Allergy and Clinical Immunology·Jennifer DebarryHolger Heine
Jun 26, 2007·Applied and Environmental Microbiology·Qiong WangJames R Cole
Nov 22, 2007·The Journal of Allergy and Clinical Immunology·Mei WangSiv Ahrné
Feb 18, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y M SjögrenE Sverremark-Ekström
Apr 4, 2009·Nature Reviews. Immunology·June L Round, Sarkis K Mazmanian
May 30, 2009·Science·Elizabeth A GriceJulia A Segre
Aug 25, 2009·Current Opinion in Immunology·Mübeccel Akdis
Sep 22, 2009·Immunity·Clare M Lloyd, Catherine M Hawrylowicz
Nov 7, 2009·Science·Elizabeth K CostelloRob Knight
Apr 10, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Renato ArianoGiovanni Passalacqua
Oct 28, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·V Doreswamy, D B Peden
Nov 10, 2010·FEMS Microbiology Ecology·Kaisa KoskinenHarri Kankaanpää
Nov 10, 2010·Nature Reviews. Immunology·Erika von Mutius, Donata Vercelli
Jan 22, 2011·Journal of Innate Immunity·Laura Maintz, Natalija Novak
Feb 18, 2011·Gut Microbes·Min ZhangJohn Y Kao
Feb 25, 2011·The New England Journal of Medicine·Markus J EgeUNKNOWN GABRIELA Transregio 22 Study Group
Mar 17, 2011·Nature Reviews. Microbiology·Elizabeth A Grice, Julia A Segre
Jun 18, 2011·The Journal of Allergy and Clinical Immunology·Stephanie BrandHarald Renz
Jul 26, 2011·The Journal of Allergy and Clinical Immunology·Hans BisgaardKaren Angeliki Krogfelt
Oct 28, 2011·FEMS Immunology and Medical Microbiology·Jiro NakayamaKenji Sonomoto
Nov 19, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B HeydenreichJ Saloga
Dec 14, 2011·The Journal of Allergy and Clinical Immunology·Thomas R AbrahamssonMaria C Jenmalm
Dec 14, 2011·Nature·Duncan Graham-Rowe
Feb 11, 2012·The Journal of Allergy and Clinical Immunology·Erika von Mutius

❮ Previous
Next ❯

Citations

Aug 11, 2012·Current Allergy and Asthma Reports·Shyamali C DharmageAdrian J Lowe
Aug 31, 2012·Current Allergy and Asthma Reports·Stacy Chin, Brian P Vickery
Feb 8, 2013·Current Allergy and Asthma Reports·Sharmilee M Nyenhuis, Sameer K Mathur
Jan 15, 2014·Indian Pediatrics·Pramod Upadhyay
Jan 15, 2013·Pediatric Research·Alexandra SittkaBernd T Schmeck
Aug 3, 2012·Environmental Health Perspectives·Sharon Levy
Feb 4, 2014·PloS One·Steven W KembelJessica L Green
Nov 7, 2012·Asia Pacific Allergy·Tari HaahtelaUNKNOWN Finnish Allergy Programme Group
Aug 21, 2013·Asia Pacific Allergy·Bernard Yu-Hor Thong
Jun 7, 2014·BMC Microbiology·Refugio Robles-SikisakaDavid T Pride
Jan 1, 2014·BMC Microbiology·Kenneth Klingenberg BarfodKaren Angeliki Krogfelt
Oct 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Graham A Rook
Aug 26, 2014·Current Allergy and Asthma Reports·Young Yoo, Matthew S Perzanowski
Feb 1, 2014·Evolution, Medicine, and Public Health·Graham A W RookCharles L Raison
Feb 18, 2016·Sports Medicine·Danielle F ShanahanRichard A Fuller
Nov 26, 2015·Nature·Diana H WallJohan Six
May 31, 2014·FEBS Letters·Veena Taneja
Apr 24, 2015·Annals of Medicine·Leena von HertzenWillem M de Vos
Jan 6, 2016·Nature Reviews. Endocrinology·Mikael Knip, Heli Siljander
Jan 16, 2016·Current Allergy and Asthma Reports·Alan C LoganSusan L Prescott
Jan 26, 2016·The Journal of Allergy and Clinical Immunology·Erika von Mutius
Apr 23, 2015·Proceedings of the National Academy of Sciences of the United States of America·Albert BarberánNoah Fierer
Jun 4, 2013·The Journal of Allergy and Clinical Immunology·Holger GarnHarald Renz
Dec 12, 2012·Trends in Ecology & Evolution·William J SutherlandAndrew R Watkinson
Sep 27, 2014·European Journal of Immunology·Lisa RizzettoDuccio Cavalieri
Dec 9, 2014·Indoor Air·William W Nazaroff
Nov 18, 2015·Seminars in Immunopathology·Yuliya SkabytskaTilo Biedermann
Mar 15, 2013·The Journal of Investigative Dermatology·Lajos Kemény, Kornélia Szabó
Mar 11, 2016·Environmental Health : a Global Access Science Source·Mark J Nieuwenhuijsen
Nov 27, 2015·Trends in Genetics : TIG·Martial Marbouty, Romain Koszul
Nov 1, 2012·Allergy·S von GuntenD Simon
Sep 19, 2012·Integrated Environmental Assessment and Management·Thomas BackhausJim Lazorchak
Apr 19, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Christopher S Reigstad, Purna C Kashyap
Jun 21, 2013·The British Journal of Dermatology·T TsakokC Flohr

❮ Previous
Next ❯

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