Environmental chemical burden in metabolic tissues and systemic biological pathways in adolescent bariatric surgery patients: A pilot untargeted metabolomic approach.

Environment International
Damaskini ValviLeda Chatzi

Abstract

Advances in untargeted metabolomic technologies have great potential for insight into adverse metabolic effects underlying exposure to environmental chemicals. However, important challenges need to be addressed, including how biological response corresponds to the environmental chemical burden in different target tissues. We performed a pilot study using state-of-the-art ultra-high-resolution mass spectrometry (UHRMS) to characterize the burden of lipophilic persistent organic pollutants (POPs) in metabolic tissues and associated alterations in the plasma metabolome. We studied 11 adolescents with severe obesity at the time of bariatric surgery. We measured 18 POPs that can act as endocrine and metabolic disruptors (i.e. 2 dioxins, 11 organochlorine compounds [OCs] and 5 polybrominated diphenyl ethers [PBDEs]) in visceral and subcutaneous abdominal adipose tissue (vAT and sAT), and liver samples using gas chromatography with UHRMS. Biological pathways were evaluated by measuring the plasma metabolome using high-resolution metabolomics. Network and pathway enrichment analysis assessed correlations between the tissue-specific burden of three frequently detected POPs (i.e. p,p'-dichlorodiphenyldichloroethene [DDE], hexachlorobenze...Continue Reading

References

Aug 30, 2001·Archives of Environmental Contamination and Toxicology·D Meironyté GuveniusK Norén
Sep 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mary S WolffMarilie D Gammon
Apr 25, 2006·Biostatistics·W Evan JohnsonAriel Rabinovic
Jun 17, 2008·International Journal of Hygiene and Environmental Health·Marie FrederiksenLisbeth E Knudsen
May 6, 2009·Bioinformatics·Tianwei YuDean P Jones
Aug 27, 2009·Bioinformatics·Kim-Anh Lê CaoSébastien Déjean
May 7, 2010·Journal of Environmental Monitoring : JEM·Victoria LinaresJosé L Domingo
Jul 19, 2013·PLoS Computational Biology·Shuzhao LiBali Pulendran
Jul 19, 2013·Annual Review of Nutrition·E Scorletti, C D Byrne
Jan 31, 2014·Environmental Science & Technology·Emma L SchymanskiJuliane Hollender
Feb 4, 2014·Endocrine Reviews·Duk-Hee LeeLaura N Vandenberg
Oct 8, 2014·Nature Reviews. Endocrinology·Christopher J Lynch, Sean H Adams
Mar 1, 2013·Metabolomics : Official Journal of the Metabolomic Society·Quinlyn A SoltowDean P Jones
Nov 7, 2015·The New England Journal of Medicine·Thomas H IngeUNKNOWN Teen-LABS Consortium
Dec 3, 2015·Diabetes Care·Simona PanunziJohn B Dixon
Jan 1, 2016·Environment International·Samira SalihovicLars Lind
Aug 9, 2016·Reproductive Toxicology·Martina KarlsenDamaskini Valvi
Oct 17, 2016·Environment International·Marina VafeiadiLeda Chatzi
Oct 21, 2016·Reproductive Toxicology·Jerrold J HeindelFrederick Vom Saal
Oct 27, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·W S DavidsonA S Shah
Mar 24, 2017·Journal of Analytical Toxicology·Nathalie ZamariolaMary Rosa Rodrigues de Marchi
Jul 29, 2017·Environment International·Damaskini ValviPhilippe Grandjean
Sep 16, 2017·Comprehensive Physiology·Erin JacksonLisa Cassis
Oct 27, 2017·Bioinformatics·Karan UppalJonathan Wren

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Citations

Apr 30, 2021·Chemical Research in Toxicology·Qi YanBeate R Ritz
Sep 24, 2021·Nature Communications·Xin HuDean P Jones
Oct 19, 2021·Environmental Science & Technology Letters·Pei ZhangCraig E Wheelock

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