Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking.

Nature Immunology
Hekla Sigmundsdottir, Eugene C Butcher

Abstract

Lymphocytes are imprinted during activation with trafficking programs (combinations of adhesion and chemoattractant receptors) that target their migration to specific tissues and microenvironments. Cytokines contribute, but, for gut and skin, evolution has cleverly adapted external cues from food (vitamin A) and sunlight (ultraviolet-induced vitamin D3) to imprint lymphocyte homing to the small intestines and T cell migration into the epidermis. Dendritic cells are essential: they process the vitamins to their active metabolites (retinoic acid and 1,25(OH)(2)D3) for presentation with antigen to lymphocytes, and they help export environmental cues through lymphatics to draining lymph nodes, to program the trafficking and effector functions of naive T and B cells.

References

Jan 1, 1988·Annual Review of Nutrition·A R Webb, M F Holick
Jan 1, 1986·Current Topics in Microbiology and Immunology·E C Butcher
Dec 15, 1995·Cell·D J Mangelsdorf, R M Evans
Apr 5, 1996·Science·E C Butcher, L J Picker
Jul 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J L Napoli
Nov 1, 1996·Journal of the American Academy of Dermatology·J H PrystowskyT L Clemens
Mar 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·B HomeyA Zlotnik
Apr 20, 2000·Experimental Dermatology·B LehmannM Meurer
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S GregoriL Adorini
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A BoonstraA O'Garra
Nov 7, 2001·The Journal of Clinical Investigation·C H KimE C Butcher
Jan 10, 2002·The Journal of Experimental Medicine·Daniel J Campbell, Eugene C Butcher
Jan 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Megumi HonjoTatsuya Sawamura
Mar 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicole H LazarusEugene C Butcher
Apr 3, 2003·The Journal of Clinical Investigation·Eric J KunkelEugene C Butcher
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chang H KimEugene C Butcher
Oct 3, 2003·Nature Reviews. Immunology·Eric J Kunkel, Eugene C Butcher
Jan 8, 2004·The Journal of Investigative Dermatology·Michael P SchönW Henning Boehncke
Mar 25, 2004·Nature Reviews. Immunology·Thomas S Kupper, Robert C Fuhlbrigge
May 5, 2004·The Journal of Experimental Medicine·Patrick SchaerliBernhard Moser
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kunio HieshimaOsamu Yoshie
Oct 16, 2004·Immunity·Makoto IwataSi-Young Song
Nov 17, 2004·Trends in Biochemical Sciences·David E Prosser, Glenville Jones
Jan 12, 2005·The Journal of Experimental Medicine·J Rodrigo MoraUlrich H von Andrian
Jan 15, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A J WardlawA Morgan
Jan 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claudia GüntherJosé M Carballido
Jul 26, 2005·Trends in Immunology·Britta Engelhardt, Richard M Ransohoff
Jul 29, 2005·Immunological Reviews·Marko Salmi, Sirpa Jalkanen
Oct 12, 2005·The Journal of Experimental Medicine·Bengt Johansson-LindbomWilliam W Agace
Oct 26, 2005·Trends in Immunology·Jochen Huehn, Alf Hamann
Dec 22, 2005·Nature Immunology·Andrew D LusterUlrich H von Andrian
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bertus EksteenDavid H Adams

❮ Previous
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Citations

Sep 18, 2010·Inflammatory Bowel Diseases·Ailsa L HartStella C Knight
Oct 12, 2011·Inflammatory Bowel Diseases·Elizabeth R MannStella C Knight
Jul 9, 2009·Zeitschrift für Rheumatologie·U Syrbe, A Hamann
Jan 15, 2011·Current Rheumatology Reports·Robert C Fuhlbrigge, Rafka Chaiban
Feb 3, 2009·Immunologic Research·Dorothy K SojkaDeborah J Fowell
Apr 25, 2012·Pathology Oncology Research : POR·Hajnalka JókaiPéter Holló
Aug 24, 2010·The British Journal of Nutrition·Yoshitaka NishiyamaShinichi Kume
Jun 26, 2010·Bone Marrow Transplantation·B G EngelhardtJ E Crowe
Nov 26, 2008·Immunology and Cell Biology·J Scott Hale, Pamela J Fink
Feb 19, 2010·Mucosal Immunology·A RayP Ray
Jun 4, 2013·Nature·Rahul RoychoudhuriNicholas P Restifo
Jan 11, 2011·Nature Immunology·Sabina A IslamAndrew D Luster
Aug 13, 2013·Nature Immunology·Michael G OverstreetDeborah J Fowell
Aug 20, 2008·Nature Immunology·Shannon K BromleyAndrew D Luster
Jan 20, 2011·Nature Immunology·Gudrun F Debes, Malissa C Diehl
May 9, 2012·Nature Medicine·Sabina A Islam, Andrew D Luster
Sep 19, 2009·Nature Reviews. Immunology·Frank O NestleBrian J Nickoloff
Jul 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Arnold HanMark M Davis
Nov 10, 2010·The Journal of Experimental Medicine·Felix C WeberStefan F Martin
Mar 6, 2013·The Journal of Experimental Medicine·Chuanwu WangChang H Kim
Aug 21, 2010·American Journal of Respiratory Cell and Molecular Biology·Jessica R Walrath, Richard F Silver
Nov 13, 2012·The Journal of Clinical Investigation·Nicolas ÇuburuJohn T Schiller
Feb 10, 2011·PloS One·Maeve K LalorHazel M Dockrell
Jun 6, 2009·Critical Reviews in Immunology·Christopher C DenucciYoji Shimizu
Jul 9, 2013·The British Journal of Nutrition·Keita NishidaShinichi Kume
Jan 5, 2014·Nature Protocols·Kristin G AndersonDavid Masopust
Jul 25, 2014·Journal of Immunology Research·Afonso P Basto, Alexandre Leitão
Jul 1, 2011·Clinical & Developmental Immunology·Manuela Buettner, Ulrike Bode
Oct 24, 2014·Immunotherapy·Gil Reynolds Diogo, Rajko Reljic

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