Environmental determinants of severity in sickle cell disease

Haematologica
Sanjay TewariDavid C Rees

Abstract

Sickle cell disease causes acute and chronic illness, and median life expectancy is reduced by at least 30 years in all countries, with greater reductions in low-income countries. There is a wide spectrum of severity, with some patients having no symptoms and others suffering frequent, life-changing complications. Much of this variability is unexplained, despite increasingly sophisticated genetic studies. Environmental factors, including climate, air quality, socio-economics, exercise and infection, are likely to be important, as demonstrated by the stark differences in outcomes between patients in Africa and USA/Europe. The effects of weather vary with geography, although most studies show that exposure to cold or wind increases hospital attendance with acute pain. Most of the different air pollutants are closely intercorrelated, and increasing overall levels seem to correlate with increased hospital attendance, although higher concentrations of atmospheric carbon monoxide may offer some benefit for patients with sickle cell disease. Exercise causes some adverse physiological changes, although this may be off-set by improvements in cardiovascular health. Most sickle cell disease patients live in low-income countries and socioe...Continue Reading

Citations

Jul 3, 2016·Journal of Pediatric Psychology·Cynthia W KarlsonTonya M Palermo
May 20, 2016·Proteomics. Clinical Applications·Raffaele Renella
Mar 5, 2016·Experimental Biology and Medicine·Alawi Habara, Martin H Steinberg
Nov 24, 2016·American Journal of Hematology·Charlotte F J van TuijnBart J Biemond
Apr 20, 2017·The New England Journal of Medicine·Frédéric B PielDavid C Rees
Apr 1, 2018·Clinical Pharmacology and Therapeutics·Ashley WaltonSusan Murphy
Nov 26, 2019·Family & Community Health·Cynthia W KarlsonMichael A Welsch
Nov 7, 2019·Journal of Pediatric Hematology/oncology·Cielle WachnianAisha A K Bruce
Apr 6, 2019·Nature Medicine·Chunliang Xu, Paul S Frenette
Jun 12, 2020·British Journal of Haematology·Oladele Simeon Olatunya
Mar 16, 2018·Nature Reviews. Disease Primers·Gregory J KatoElliott P Vichinsky
Feb 6, 2020·Frontiers in Genetics·Bonnie R JoubertKimberly A McAllister
Mar 12, 2020·Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo·Débora Cristina Fontes LeiteGabriel Dantas Lopes
May 31, 2017·Clinical Journal of Gastroenterology·Yousef Al TalhiYasmin Yousef
Dec 8, 2019·Journal of the American Society of Nephrology : JASN·Kabir O OlaniranSahir Kalim
Jun 1, 2017·Expert Opinion on Investigational Drugs·Nicola Conran, David C Rees
Feb 6, 2020·Vector Borne and Zoonotic Diseases·Tânia Cristina Benetti SoaresPaulo Eduardo Neves Ferreira Velho
Oct 27, 2020·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Talal QadahRaed Felimban
Feb 9, 2021·Frontiers in Cell and Developmental Biology·Alba Saenz de Villaverde CortabarriaPanicos Shangaris
Jan 6, 2021·Blood Cells, Molecules & Diseases·Immacolata TartaglioneAndrew D Campbell
Mar 8, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Anke M TukkerKimberly A McAllister
May 20, 2021·The Clinical Journal of Pain·Zachary RamsayMonika Asnani
Mar 10, 2020·Complementary Therapies in Medicine·Ashley N Junghans-RutelonisMelanie L Brown

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