Environmental effects on pulmonary mechanics and the response to inhaled methacholine

Pediatric Pulmonology
P D SlyW Habre

Abstract

To investigate the role of environmental exposure from birth on airway and lung parenchymal responsiveness to inhaled methacholine (Mch), three litters of puppies (n = 14) were studied when 8-10 weeks of age. Two litters, one mongrel (n = 7) and one foxhound-beagle cross (n = 3), were born and raised in a clean animal house environment (clean mongrels and clean cross, respectively). Another litter of mongrels was born (n = 4) and raised in an external environment (external mongrels), exposed to normal rural environmental contaminants. Animals were studied open-chested with alveolar capsules used to partition mechanics into airway and parenchymal components. Lung mechanics were measured after abrupt flow interruptions. The animals born and raised in the external environment were significantly more responsive to inhaled Mch than those born and raised in the clean environment. This finding was true for both airway and parenchymal responsiveness. The group mean effective dose of Mch that produced a doubling of airway resistance (ED200Raw) for the external mongrel group was 4.40 mg/ml compared with 19.44 mg/ml for the clean mongrel group and 16.34 mg/ml for the clean cross group (P < 0.02). The group mean effective dose of Mch that ...Continue Reading

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Citations

Oct 15, 2013·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·T SheehyS Sharma
May 1, 2013·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·C A McGowanF M McAuliffe
Mar 31, 2016·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·M J WhitrowV M Moore
Mar 13, 2014·Journal of Epidemiology and Community Health·Camilla NykjaerJanet E Cade
Apr 25, 2014·Journal of Epidemiology and Community Health·C Donat-VargasM Bes-Rastrollo
Oct 24, 2007·Cadernos de saúde pública·Maria do Rosário Gondim PeixotoPaulo César Brandão Veiga Jardim

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