Environmental enrichment-behavior-oxidative stress interactions in the aged rat: issues for a therapeutic approach in human aging

Annals of the New York Academy of Sciences
C I FernándezO López

Abstract

The effects of environment enrichment on motor activity, exploration, and cognitive performances were studied in aged rats. Both nonimpaired (NI) and impaired (I) rats were submitted to daily training in a complex-enriched environment (cEE) for 60 days. Animals were examined at spatial water maze task, passive avoidance test, open-field test, and sensorimotor coordination tasks (bridges test and Marshall scales). At the end of experiments, animals were killed for brain biochemical determinations (gluthatione content and specific-ChAT activity). Results after the first evaluation (before training) corroborate that the aged rat population showed a heterogeneity in behavioral patterns like that observed in humans. Also, cEE modified exploration activity, cognition, motor functions, and biochemical markers in both NI and I groups, but changes reached significant relevance for the last group. It is significant that neurotrophins, "novo" synthesis of neurotransmitters, and oxidative stress levels may mediate the observed changes, indicating that the aged brain still has appreciable plasticity in response to well-manipulated environmental stimulation. Finally, our results also support the novel concepts and programs in prevention/redu...Continue Reading

References

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Citations

Sep 8, 2006·Biogerontology·Keiko UnnoMinoru Hoshino
May 28, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tomasz SchneiderRyszard Przewłocki
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Aug 29, 2016·Journal of Huntington's Disease·Fabian KreilausAndrew M Jenner
Apr 1, 2017·Translational Neurodegeneration·Bin-Yin LiSheng-Di Chen
Dec 30, 2015·Experimental Neurobiology·Darine Froy N MabungaChan Young Shin
Jun 26, 2020·Frontiers in Aging Neuroscience·Branden S KolarikCraig E L Stark
Dec 20, 2018·Brain Plasticity·María Llorens-Martín
Mar 1, 2021·Behavioural Brain Research·Michael R Duggan, Vinay Parikh

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