Environmental enrichment improves pain sensitivity, depression-like phenotype, and memory deficit in mice with neuropathic pain: role of NPAS4

Psychopharmacology
Xing-Ming WangZhi-Qiang Zhou

Abstract

Patients suffering from neuropathic pain have a higher incidence of depression and cognitive decline. Although environment enrichment (EE) may be effective in the treatment of neuropathic pain, the precise mechanisms underlying its actions remain determined. The aim of the study was to examine the molecular mechanisms underlying the EE's beneficial effects in mice with neuropathic pain. EE attenuated the pain threshold reduction, depression-like phenotype, and memory deficit in mice after chronic constriction injury (CCI). Furthermore, EE attenuated decreased neurogenesis and increased inflammation in the hippocampus of mice with neuropathic pain after CCI. Moreover, the suppression of adult hippocampal neurogenesis by temozolomide antagonized the beneficial effects of EE on depression-like phenotype and cognitive deficit in the mice with neuropathic pain. In addition, lipopolysaccharide-induced increase in tumor necrosis factor-α (TNF-α) in the hippocampus antagonized the beneficial effects of EE for these behavioral abnormalities in mice with neuropathic pain. Knock-down of NPAS4 (neuronal PAS domain protein 4) in the hippocampus by lentivirus targeting NPAS4 blocked these beneficial effects of EE in the mice with neuropathic...Continue Reading

References

Mar 12, 2003·Current Pain and Headache Reports·Robert P HartMichael F Martelli
Nov 12, 2003·Archives of Internal Medicine·Matthew J BairKurt Kroenke
Aug 4, 2006·The Journal of Pain : Official Journal of the American Pain Society·Vanja Duric, Kenneth E McCarson
Aug 23, 2006·Nature Reviews. Neuroscience·Jess Nithianantharajah, Anthony J Hannan
Aug 30, 2007·Nature Neuroscience·Amar Sahay, Rene Hen
Jan 11, 2011·Progress in Neurobiology·Orla MoriartyDavid P Finn
Feb 4, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Wen-Jie RenXian-Guo Liu
Oct 25, 2011·Current Opinion in Pharmacology·Norikazu KiguchiShiroh Kishioka
Jan 28, 2012·Brain, Behavior, and Immunity·Lauren L WilliamsonStaci D Bilbo
Aug 3, 2012·Biological Psychiatry·Cristina Alba-DelgadoEsther Berrocoso
Jun 26, 2013·British Journal of Anaesthesia·A Ellis, D L H Bennett
Nov 10, 2013·Nature·Brenda L BloodgoodMichael E Greenberg
Aug 15, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Junfang WuAlan I Faden
Jan 1, 2015·Behavioural Brain Research·Emily J JaehneMartin D Lewis
May 1, 2015·Neurology·Francisca S ThenSteffi G Riedel-Heller
Aug 28, 2015·Pain·A Vania ApkarianJohn A Kessler
Dec 15, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gregory D Clemenson, Craig E L Stark
Dec 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Fong Chan ChoyMartin D Lewis
Dec 23, 2015·International Journal of Molecular Sciences·Fong Chan ChoyMartin D Lewis
Mar 19, 2016·Trends in Neurosciences·Xiaochen Sun, Yingxi Lin
Jun 30, 2016·Pain·Peter M GraceLinda R Watkins
Jan 1, 2015·Neurobiology of Stress·Brunno R LevoneOlivia F O'Leary
Apr 1, 2017·International Journal of Molecular Sciences·Verica Vasic, Mirko H H Schmidt

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Citations

Jan 28, 2020·The European Journal of Neuroscience·Mélanie KremerIpek Yalcin
May 23, 2020·Perspectives on Behavior Science·Sarah L WitheyBrian D Kangas
Dec 18, 2020·The European Journal of Neuroscience·Maxime FouyssacDavid Belin
Nov 13, 2020·Frontiers in Pharmacology·Guadalupe Del Carmen Baeza-FloresVinicio Granados-Soto
Sep 28, 2020·Neuroscience and Biobehavioral Reviews·Ana Margarida CunhaHugo Leite-Almeida

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