Environmental enrichment reduces the mnemonic and neural benefits of estrogen

Neuroscience
Jodi E Gresack, Karyn M Frick

Abstract

The degree to which memory is enhanced by estrogen replacement in postmenopausal women may depend on environmental factors such as education. The present study utilized an animal model of environmental enrichment to determine whether environmental factors influence the mnemonic and neural response to estrogen. Female mice were raised in standard (SC) or enriched (EC) conditions from weaning until adulthood (7 months). All mice were ovariectomized at 10 weeks, and tested in object recognition and water-escape motivated radial arm maze (WRAM) tasks at 6 months. Each day at the completion of training, mice received injections of 0.1 mg/kg cyclodextrin-encapsulated 17-beta-estradiol (E2), 0.2 mg/kg E2, or cyclodextrin vehicle (VEH). At the completion of behavioral testing, hippocampal levels of the presynaptic protein synaptophysin and of brain-derived neurotrophic factor (BDNF) were measured. Enrichment effects were evident in VEH-treated mice; relative to SC-VEH females, EC-VEH females committed fewer working memory errors in the WRAM and exhibited increased hippocampal synaptophysin levels. Estrogen effects depended on environmental conditions. E2 (0.2 mg/kg) improved object memory only in SC females. The same dose improved work...Continue Reading

References

Sep 29, 1978·Brain Research·M R RosenzweigH Morimoto
Nov 1, 1988·Behavioural Brain Research·A Ennaceur, J Delacour
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R JahnP Greengard
Sep 1, 1985·Journal of Pharmaceutical Sciences·J Pitha, J Pitha
Oct 27, 1995·Science·H Thoenen
Feb 1, 1995·The Journal of Endocrinology·M P CareyE R de Kloet
Nov 1, 1994·Behavioral and Neural Biology·V Luine, M Rodriguez
Dec 1, 1996·Journal of Neurocytology·M E CalhounP R Mouton
Jun 1, 1997·Brain Research. Brain Research Reviews·S J Lupien, B S McEwen
Oct 10, 1997·Neurobiology of Learning and Memory·M G Packard, L A Teather
Oct 23, 1997·Neuroreport·M G Packard, L A Teather
Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·D D MurphyM Segal
Nov 5, 1998·Psychoneuroendocrinology·L E Carlson, B B Sherwin
Apr 3, 1999·Annals of Internal Medicine·N L KeatingJ Z Ayanian
Apr 15, 1999·Annual Review of Neuroscience·A K McAllisterD C Lo
May 14, 1999·Journal of the American Geriatrics Society·K MatthewsJ M Zmuda
Oct 9, 1999·Neuroscience Research·J WidenfalkP Thorén
Sep 20, 2000·Neurology·J VergheseR B Lipton
Mar 21, 2001·Behavioral Neuroscience·K M Frick, J Berger-Sweeney
Jan 5, 2002·Neurobiology of Aging·Elvire VaucherKeith B J Franklin
Dec 12, 2002·Stress : the International Journal on the Biology of Stress·Cheryl M McCormickNicholas W Miller
Dec 21, 2002·The European Journal of Neuroscience·Lisa A TeatherRichard J Wurtman
May 29, 2003·JAMA : the Journal of the American Medical Association·Stephen R RappUNKNOWN WHIMS Investigators
May 30, 2003·Learning & Memory·Karyn M FrickJoanne Berger-Sweeney
Jun 18, 2003·Endocrinology·Victoria N LuineNeil J Maclusky
Dec 17, 2003·Behavioral Neuroscience·Karyn M Frick, Jodi E Gresack

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Citations

May 24, 2005·Hormones and Behavior·Eugenia PapalexiEfthimia Kitraki
Aug 30, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephanie M FernandezKaryn M Frick
Jun 1, 2014·Frontiers in Neuroendocrinology·Ashley M Fortress, Karyn M Frick
Nov 28, 2013·Proceedings of the National Academy of Sciences of the United States of America·Victor W HendersonWendy J Mack
Feb 20, 2016·Progress in Neurobiology·E B Engler-ChiurazziJ W Simpkins
Sep 11, 2014·Hormones and Behavior·Victoria N Luine
Oct 23, 2012·Neurobiology of Learning and Memory·Juliana Trevisan da RochaGilson Zeni
Jan 27, 2010·Biochimica Et Biophysica Acta·Cindy K Barha, Liisa A M Galea
Nov 17, 2009·Biochimica Et Biophysica Acta·Karyn M FrickLauren L Harburger
Apr 29, 2009·Neurobiology of Aging·Hayat HaratiAlexandra Barbelivien
Aug 21, 2007·Behavioural Brain Research·Lauren L HarburgerKaryn M Frick
Mar 21, 2007·Neuroscience and Biobehavioral Reviews·Ekrem DereMaria A De Souza Silva
Feb 29, 2008·Hippocampus·Fenghua ChenJens R Nyengaard
Mar 24, 2009·The European Journal of Neuroscience·Ingegerd SöderströmTommy Olsson
Jun 3, 2008·Journal of Neuroendocrinology·V N Luine
Jun 9, 2006·Pharmacology, Biochemistry, and Behavior·Jodi E Gresack, Karyn M Frick
Apr 20, 2006·Neurobiology of Aging·Lauren L HarburgerKaryn M Frick
Mar 15, 2006·Neurobiology of Learning and Memory·Alicia A WalfCheryl A Frye
Aug 9, 2005·Pharmacology, Biochemistry, and Behavior·Cheryl A Frye, Madeline E Rhodes
Aug 8, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Guillermo S Moreno-PiovanoJorge G Ramos
May 20, 2008·Neurobiology of Learning and Memory·Joshua S TalboomHeather A Bimonte-Nelson
Aug 19, 2014·Behavioural Brain Research·Jennifer J TuscherKaryn M Frick
May 11, 2017·Journal of Neuroendocrinology·P A S SheppardE Choleris
Sep 1, 2009·Expert Review of Endocrinology & Metabolism·Antonella GasbarriCarlos Tomaz

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